The Hypoglycaemic Activity of Mengkudu (Morinda Citrifolia)
Diabetes mellitus has existed for at least 2000 years and has been treated with materials derived from plants in many cultures of the world. The mengkudu (Morinda citrifolia) are known for countless medicinal values and the ripe fruits were being used traditionally in Malaysia for the treatment f...
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| 主要作者: | |
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| 格式: | Thesis |
| 語言: | English English |
| 出版: |
2001
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| 主題: | |
| 在線閱讀: | http://psasir.upm.edu.my/id/eprint/9316/1/FSAS_2001_49.pdf |
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| 總結: | Diabetes mellitus has existed for at least 2000 years and has been treated with
materials derived from plants in many cultures of the world. The mengkudu
(Morinda citrifolia) are known for countless medicinal values and the ripe fruits
were being used traditionally in Malaysia for the treatment for diabetes mellitus. This
study was carried out to verify the hypoglycaemic property and its possible effect on
insulin secretion. Freeze-dried aqueous extracts of various doses of 3 mg/lkg, 30 mg/kg
and 300 mg/kg were administered to normal rats in an acute effect study and the
doses of 3 mg/kg, 30 mg/kg, 300 mg/kg, 600 mg/kg, 900 mg/kg and 1200 mg/kg were
administered to streptozotocin induced type 2 diabetic rats in a chronic effect study
in an Oral Glucose Tolerance Test (OGTI). Results from the choric effect study
showed that the 300 mg/kg dose treated rats had an apparent hypoglycaemic effect as
evident from the blood glucose level measured as the area under the OGTT curve
(AUC: 4370.70 ± 99.13 mg%min) after 6 weeks of oral administration.
Hypoglycaemic activity was also observed in the 600 mg/kg dose after 5 weeks of
oral administration (AUC: 4486.70 ± 35.60 mg%min), the 900 mg/kg dose after 4
weeks of oral administration (AUC: 4340.40 ± 72.90 mg%min) and the 1200mglkg
dose after 4 weeks of oral administration (AUC: 4554.00 ± 49.80 mg%min). All the Ave values were significantly lower compared to control. The aqueous extracts
were also able' to impede the rate of glucose increase and enhance the glucose
clearance. However, the results from the insulin assay did not show any significant
change in the insulin release profile as compared to control. As a conclusion, the
aqueous extract of mengkudu (Morinda citrifolia) fruit preparations in the doses of
300mglkg, 600mg/kg, 900mg/kg and 1200 mg/kg might contain plant compounds
that have substantial hypoglycemic property only in the chronic effect study but did
not affect the insulin secretion in the type 2 diabetic rats. Future studies should be
carried out in order to further discover its mechanisms of action, isolation and
identification of the hypoglycaemic components particularly with regard to the
healing of diabetes by means of plant resources. |
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