Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities

The study on Murraya koenigii (curry leaf) involves extraction, separations by using various chromatographic methods and structural determination by spectroscopic techniques such as IR, NMR including 2D-NMR and MS. The structures of the compounds were also elucidated by comparison with the previ...

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Main Author:	Ahmad, Kartini
Format:	Thesis
Language:	English English
Published:	1999
Subjects:	Chemical elements - Spectra Curry leaf tree
Online Access:	http://psasir.upm.edu.my/id/eprint/9484/1/FSAS_1999_25_A.pdf
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id	my-upm-ir.9484
record_format	uketd_dc
spelling	my-upm-ir.94842013-09-25T08:04:49Z Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities 1999-05 Ahmad, Kartini The study on Murraya koenigii (curry leaf) involves extraction, separations by using various chromatographic methods and structural determination by spectroscopic techniques such as IR, NMR including 2D-NMR and MS. The structures of the compounds were also elucidated by comparison with the previous work. Isolation works on stem bark of the plant yielded mahanimbine (31), girinimbine (32), murray anine (47), murrayazoline (48), murrayacine (49) and sucrose (50). From the leaves, five compounds were isolated and elucidated. Two of them were long chain compounds, Il-decylhenecosane (51a) and methoxydotriacontane (51b), isolated as a mixture and the other compounds were mahanimbine (31), ethyl octadecanoate (52) and mahanine (53). Further study on the roots of the same plant afforded four compounds including girinimbine (32), murrayanine (47), together with 3-methylcarbazole (54) and murrayafoline A(55).Crude extract and isolated compounds from various part of this plant were screened for antimicrobial activity using disc diffusion method, cytotoxic activity using rnicrotitration method and antitumor promoting activity using Epstein B arr virus activation assay. The crude extracts of the roots and pure isolated compound including mah animbine (31) , girinimbine (32), mahanine (53) and murrayafoline A (55) exhibited significant cytotoxicity activity against CEM-SS cell line with IC₅₀ 3 µg/ml. G irinimbine (32), although did not show any cytotoxic activity against CEM-SS cell line, the compound however inhibited EBV-activation (100%) in the antitumor promoting assay . The pet.ether, CHCl₃ and MeOH crude extracts of leaves, the methanol extract of stem bark, mah animbine (31) and girinimbine (32) failed to show significant antimicrobial activity, while the pet.ether and the chloroform crude extracts of the stem bark exhibited weak antibacterial activity against Bacillus cereus. Chemical elements - Spectra Curry leaf tree 1999-05 Thesis http://psasir.upm.edu.my/id/eprint/9484/ http://psasir.upm.edu.my/id/eprint/9484/1/FSAS_1999_25_A.pdf application/pdf en public masters Universiti Putra Malaysia Chemical elements - Spectra Curry leaf tree Faculty of Science and Environmental Studies English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
topic	Chemical elements - Spectra Curry leaf tree
spellingShingle	Chemical elements - Spectra Curry leaf tree Ahmad, Kartini Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
description	The study on Murraya koenigii (curry leaf) involves extraction, separations by using various chromatographic methods and structural determination by spectroscopic techniques such as IR, NMR including 2D-NMR and MS. The structures of the compounds were also elucidated by comparison with the previous work. Isolation works on stem bark of the plant yielded mahanimbine (31), girinimbine (32), murray anine (47), murrayazoline (48), murrayacine (49) and sucrose (50). From the leaves, five compounds were isolated and elucidated. Two of them were long chain compounds, Il-decylhenecosane (51a) and methoxydotriacontane (51b), isolated as a mixture and the other compounds were mahanimbine (31), ethyl octadecanoate (52) and mahanine (53). Further study on the roots of the same plant afforded four compounds including girinimbine (32), murrayanine (47), together with 3-methylcarbazole (54) and murrayafoline A(55).Crude extract and isolated compounds from various part of this plant were screened for antimicrobial activity using disc diffusion method, cytotoxic activity using rnicrotitration method and antitumor promoting activity using Epstein B arr virus activation assay. The crude extracts of the roots and pure isolated compound including mah animbine (31) , girinimbine (32), mahanine (53) and murrayafoline A (55) exhibited significant cytotoxicity activity against CEM-SS cell line with IC₅₀ 3 µg/ml. G irinimbine (32), although did not show any cytotoxic activity against CEM-SS cell line, the compound however inhibited EBV-activation (100%) in the antitumor promoting assay . The pet.ether, CHCl₃ and MeOH crude extracts of leaves, the methanol extract of stem bark, mah animbine (31) and girinimbine (32) failed to show significant antimicrobial activity, while the pet.ether and the chloroform crude extracts of the stem bark exhibited weak antibacterial activity against Bacillus cereus.
format	Thesis
qualification_level	Master's degree
author	Ahmad, Kartini
author_facet	Ahmad, Kartini
author_sort	Ahmad, Kartini
title	Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
title_short	Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
title_full	Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
title_fullStr	Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
title_full_unstemmed	Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities
title_sort	chemical constituents of murraya koenigii (rutaceae) and their biological activities
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Science and Environmental Studies
publishDate	1999
url	http://psasir.upm.edu.my/id/eprint/9484/1/FSAS_1999_25_A.pdf
_version_	1747810963943325696

Chemical Constituents of Murraya Koenigii (Rutaceae) and Their Biological Activities

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