Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be th...
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my-upm-ir.95342012-08-27T06:48:59Z Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications 2003-01 Thurai Raja, Priadarishni Ramanujam Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be the result of malpractice in backyard farming. The mechanism of NOV infection is still not clearly understood, making it difficult to validate any effective drug candidates. Bearing this in mind, a phage display random peptide library was used to identify peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence represented 97% of the total phage screened from the third round of biopanning against NOV strain AF2240. This phage was characterized and both cyclic and linear synthetic peptides bearing the homologous sequence were synthesized. Newcastle Disease Virus - Malaysia. Peptides - Malaysia. 2003-01 Thesis http://psasir.upm.edu.my/id/eprint/9534/ http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf application/pdf en public phd doctoral Universiti Putra Malaysia Newcastle Disease Virus - Malaysia. Peptides - Malaysia. Faculty of Science and Environmental Studies English |
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Universiti Putra Malaysia |
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PSAS Institutional Repository |
language |
English English |
topic |
Newcastle Disease Virus - Malaysia. Peptides - Malaysia. |
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Newcastle Disease Virus - Malaysia. Peptides - Malaysia. Thurai Raja, Priadarishni Ramanujam Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
description |
Newcastle disease, a highly contagious disease of the avian species is
caused by the Newcastle disease virus (NOV). In Malaysia there have been 29
outbreaks of NOV reported this year alone. In spite of the availability of mass
vaccination programmes, these sporadic outbreaks are believed to be the result
of malpractice in backyard farming. The mechanism of NOV infection is still not
clearly understood, making it difficult to validate any effective drug candidates.
Bearing this in mind, a phage display random peptide library was used to identify
peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence
represented 97% of the total phage screened from the third round of biopanning
against NOV strain AF2240. This phage was characterized and both cyclic and
linear synthetic peptides bearing the homologous sequence were synthesized. |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Thurai Raja, Priadarishni Ramanujam |
author_facet |
Thurai Raja, Priadarishni Ramanujam |
author_sort |
Thurai Raja, Priadarishni Ramanujam |
title |
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
title_short |
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
title_full |
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
title_fullStr |
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
title_full_unstemmed |
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
title_sort |
peptide ligands that interact with newcastle disease virus: selection, characterization and applications |
granting_institution |
Universiti Putra Malaysia |
granting_department |
Faculty of Science and Environmental Studies |
publishDate |
2003 |
url |
http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf |
_version_ |
1747810975647531008 |