Sequence Analysis of the L Gene of Newcastle Disease Virus Strain AF2240
Newcastle disease is an avian disease which causes a devastating effect in commercial poultry production. The causative agent for this fatal disease is Newcastle disease virus (NDV) which contains six structural proteins; nucleocapsid (NP). phospho (P). matrix (M), fusion (F). haemagglutinin-neur...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English English |
| Published: |
2003
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/9566/1/FSAS_2003_26.pdf |
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| Summary: | Newcastle disease is an avian disease which causes a devastating effect in
commercial poultry production. The causative agent for this fatal disease is
Newcastle disease virus (NDV) which contains six structural proteins; nucleocapsid
(NP). phospho (P). matrix (M), fusion (F). haemagglutinin-neuraminidase (HN) and
large (L) proteins. The L protein of NDV is important not only as a multifunctional
enzyme but also as an RNA-dependent RNA polymerase. This protein may carry out
all of the enzymatic steps in transcription such as initiation, elongation and
cotranscriptional modification of RNAs including capping, methylation and
polyadenylation. Therefore, this study was carried out to determine the L gene
sequence and its predicted translated product, and to analyse the primary and
secondary structures of the L protein of the local NDV strain AF2240. In order to
identify the conserved functional domains and motifs within the L protein, the amino
acid composition of the L protein of strain AF2240 was compared with those of other
NDV strains. |
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