Antioxidant and functional cosmeceutical properties of leaves of three melastomataceae species in nanoemulsion system for topical applications
Melastomataceae commonly known as “Senduduk” has been recognized for its potential for the treatment of various ailments. The leaves of Melastoma malabathricum L., Clidemia hirta (L.) D. Don and Melastoma malabathricum varr. alba were studied for their antioxidant and functional cosmeceuticals...
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| Format: | Thesis |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/97856/1/IPPH%202020%205%20UPMIR.pdf |
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| Summary: | Melastomataceae commonly known as “Senduduk” has been recognized for its
potential for the treatment of various ailments. The leaves of Melastoma
malabathricum L., Clidemia hirta (L.) D. Don and Melastoma malabathricum varr.
alba were studied for their antioxidant and functional cosmeceuticals properties. The
levels of total antioxidant activities were evaluated using multiple assay and the
result shows the correlation and cluster analysis (CA) were found that different
antioxidant assays significantly correlated at (P<0.05). The high total antioxidant
assay can be seen mainly from the ethyl acetate and methanolic extract of three
Melastoma species. The functional cosmetic properties such as sun protection factor
(SPF), anti-tyrosinase (whitening activity) and anti-microbial test were noticed to be
influenced by the more polar solvents. The simplex centroid mixture design was
found to be the best tools and was successfully developed the optimal ratio composed
of 30:40:30 mixtures. The leaves of Melastoma leaves species exhibited positive
result for tannin/polyphenolic, flavonoids and also saponin. Terpenes, terpenoids,
hydrocarbon, fatty acid derivatives, phenol and carbohydrate (amino acids) were
significant bioactive compounds identified in the Melastoma leaves using GCMS.
Rutin and quercetin of flavonoid compounds were also detected using HPLC. The
highlights of the development and characterization of nanoemulsion formulation
revealed that the cream has smooth and silky texture and exhibited Melastoma
nanoemulsion can act as natural photoprotective agents and natural inhibitors for
elastase and collagenase activity on skin. The in vivo results showed Melastoma
nanoemulsion can be used significantly as good moisturizing cream as it increases
the hydration level and reduce the rate of transpiration (TEWL) after 30 minutes of
application and presents as a good anti-wrinkles properties after four weeks of
applications. Hence, the innovations of nanoemulsion of plant based materials
containing active extract of Melastoma leaves yield good and effective cosmeceutical products particularly for improving skin conditions and ready to be
utilized as one of the cosmeceutical ingredients. |
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