Clinical pathology and radiological assesment of feline chronic gingivostomatitis

Feline chronic gingivostomatitis (FCGS) is a severe inflammatory oral disease of cats that often refractory to treatment. The etiology is unknown but it has been attributed to bacterial agents, viral agents, and immunologic factors. The association of FCGS to dentoalveolar lesions is poorly de...

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Main Author:	Hussain, Haidary Mohammad
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Cats - Diseases Veterinary dentistry Mouth - Diseases - Case studies
Online Access:	http://psasir.upm.edu.my/id/eprint/97874/1/FPV%202021%206%20UPMIR.pdf
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spelling	my-upm-ir.978742022-07-07T00:29:45Z Clinical pathology and radiological assesment of feline chronic gingivostomatitis 2020-12 Hussain, Haidary Mohammad Feline chronic gingivostomatitis (FCGS) is a severe inflammatory oral disease of cats that often refractory to treatment. The etiology is unknown but it has been attributed to bacterial agents, viral agents, and immunologic factors. The association of FCGS to dentoalveolar lesions is poorly defined. This study presents the clinical, pathological, immunofluorescence, and computed tomographic findings of 15 cats with FCGS and 7 without FCGS. Clinical examination of the oral cavity was performed and oral pathological lesions were recorded. Blood, oral swab, and excisional biopsy from palatoglossal fold were collected under general anesthesia. Histopathological analysis and immunofluorescence staining for immune cells, CD4 and CD8 were performed on the oral tissue biopsies. The swab samples were analyzed for the presence of Bartonella henselae and Pasteurella multocida using PCR and bacteria culture, respectively. Blood was subjected to hematological and biochemical analysis and screened for feline calicivirus (FCV), feline herpesvirus (FHV), feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV). Computed tomography (CT scan) was performed to elaborate on the dentoalveolar lesions. The main clinical findings were halitosis (73.3%), Anorexia (60%), dysphagia (53.3%), bleeding gum (33.3%), weight loss (26.7%), and ptyalism (20%). CT scan revealed different types of dentoalveolar lesions where furcation (73.3%), edentulous (66.6%), horizontal bone loss (66.6%), dental resorption (53.3%), vertical bone loss (40%), fracture (33.3%), and impacted tooth (13.3%). Viral screening was positive for FCV (86.6%), FHV (73.3%), FIV (22.2%) and FeLV (5.6%). The blood and oral swabs were negative for Bartonella henselae. Histopathologically, the excisional biopsies were characterized by the infiltration of inflammatory cells in the epithelium and lamina propria. It is worthy to note that, the present study reveals that, viruses like FCV, FHV, and FIV contribute greatly to the cause of FCGS and the study also discovered that, FCGS is associated with various types of dentoalveolar lesions. Cats - Diseases Veterinary dentistry Mouth - Diseases - Case studies 2020-12 Thesis http://psasir.upm.edu.my/id/eprint/97874/ http://psasir.upm.edu.my/id/eprint/97874/1/FPV%202021%206%20UPMIR.pdf text en public masters Universiti Putra Malaysia Cats - Diseases Veterinary dentistry Mouth - Diseases - Case studies Radzi, Rozanaliza
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Radzi, Rozanaliza
topic	Cats - Diseases Veterinary dentistry Mouth - Diseases - Case studies
spellingShingle	Cats - Diseases Veterinary dentistry Mouth - Diseases - Case studies Hussain, Haidary Mohammad Clinical pathology and radiological assesment of feline chronic gingivostomatitis
description	Feline chronic gingivostomatitis (FCGS) is a severe inflammatory oral disease of cats that often refractory to treatment. The etiology is unknown but it has been attributed to bacterial agents, viral agents, and immunologic factors. The association of FCGS to dentoalveolar lesions is poorly defined. This study presents the clinical, pathological, immunofluorescence, and computed tomographic findings of 15 cats with FCGS and 7 without FCGS. Clinical examination of the oral cavity was performed and oral pathological lesions were recorded. Blood, oral swab, and excisional biopsy from palatoglossal fold were collected under general anesthesia. Histopathological analysis and immunofluorescence staining for immune cells, CD4 and CD8 were performed on the oral tissue biopsies. The swab samples were analyzed for the presence of Bartonella henselae and Pasteurella multocida using PCR and bacteria culture, respectively. Blood was subjected to hematological and biochemical analysis and screened for feline calicivirus (FCV), feline herpesvirus (FHV), feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV). Computed tomography (CT scan) was performed to elaborate on the dentoalveolar lesions. The main clinical findings were halitosis (73.3%), Anorexia (60%), dysphagia (53.3%), bleeding gum (33.3%), weight loss (26.7%), and ptyalism (20%). CT scan revealed different types of dentoalveolar lesions where furcation (73.3%), edentulous (66.6%), horizontal bone loss (66.6%), dental resorption (53.3%), vertical bone loss (40%), fracture (33.3%), and impacted tooth (13.3%). Viral screening was positive for FCV (86.6%), FHV (73.3%), FIV (22.2%) and FeLV (5.6%). The blood and oral swabs were negative for Bartonella henselae. Histopathologically, the excisional biopsies were characterized by the infiltration of inflammatory cells in the epithelium and lamina propria. It is worthy to note that, the present study reveals that, viruses like FCV, FHV, and FIV contribute greatly to the cause of FCGS and the study also discovered that, FCGS is associated with various types of dentoalveolar lesions.
format	Thesis
qualification_level	Master's degree
author	Hussain, Haidary Mohammad
author_facet	Hussain, Haidary Mohammad
author_sort	Hussain, Haidary Mohammad
title	Clinical pathology and radiological assesment of feline chronic gingivostomatitis
title_short	Clinical pathology and radiological assesment of feline chronic gingivostomatitis
title_full	Clinical pathology and radiological assesment of feline chronic gingivostomatitis
title_fullStr	Clinical pathology and radiological assesment of feline chronic gingivostomatitis
title_full_unstemmed	Clinical pathology and radiological assesment of feline chronic gingivostomatitis
title_sort	clinical pathology and radiological assesment of feline chronic gingivostomatitis
granting_institution	Universiti Putra Malaysia
publishDate	2020
url	http://psasir.upm.edu.my/id/eprint/97874/1/FPV%202021%206%20UPMIR.pdf
_version_	1747813819714895872

Clinical pathology and radiological assesment of feline chronic gingivostomatitis

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