Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia

According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, han...

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Main Author:	Soo, Tze Hui
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Cartilage Diseases
Online Access:	http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf
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spelling	my-upm-ir.979572022-07-13T07:59:40Z Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia 2021-05 Soo, Tze Hui According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, hands, feet, and spine and is relatively common in shoulder and hip joints. The prevalence of knee OA in Malaysia was estimated to be 10% to 20% of the elderly population and more common in adults aged 40 years and above. Self-regeneration processes are only initiated when damage reaches the subchondral bones. Sudden and rapid applied excessive force would not allow for sufficient fluid to move through the matrix for shock absorption, thus allowing the stress to be applied fully on the macromolecules network causing micro tears and matrix injury. In severe cases, there might be segmental loss of cartilage. Macromolecules synthesized by chondrocytes are inadequate to fill the gaps caused by injuries. By times, OA start to set in causing chronic pain and instability. MRI is the only imaging of choice that able to provide structural details as well as biochemical information about the articular cartilage. Moreover, it would be desirable for MRI to provide an evaluation of the underlying cartilage physiology including providing information about the status of prostaglandins (PGs) and collagen matrices. T2 mapping is straightforward to perform and is sensitive to changes in collagen as well as water content, but less sensitive in detection of early degeneration. A retrospective and prospective cross sectional study using secondary and primary data to provide information on the value of T2 mapping of knee articular cartilage (medial and lateral compartment) in asymptomatic young adult and its association with gender, age and body mass index was carried out over a period of 2 years from December 2018 to December 2020. The data was then post processed with T2 mapping programming via Matlab R2019b version and further analysed with SPSS version 26. Overall, we has shown that female has slightly higher mean T2 value (49.1731ms to 51.9192ms) as compared to male population (48.4147ms to 49.4647ms) out of 30 volunteers recruited. We concluded that as we age, the T2 value increases which signify the occurrence of OA has set in slowly. In our study, T2 value increases as BMI increase as well. With 3 independent variables tested, our result were consistent with previous studies even though there was no strong association ( p > 0.05) obtained. Cartilage Diseases 2021-05 Thesis http://psasir.upm.edu.my/id/eprint/97957/ http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf text en public masters Universiti Putra Malaysia Cartilage Diseases Abu Hassan, Hasyma
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Abu Hassan, Hasyma
topic	Cartilage Diseases
spellingShingle	Cartilage Diseases Soo, Tze Hui Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
description	According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, hands, feet, and spine and is relatively common in shoulder and hip joints. The prevalence of knee OA in Malaysia was estimated to be 10% to 20% of the elderly population and more common in adults aged 40 years and above. Self-regeneration processes are only initiated when damage reaches the subchondral bones. Sudden and rapid applied excessive force would not allow for sufficient fluid to move through the matrix for shock absorption, thus allowing the stress to be applied fully on the macromolecules network causing micro tears and matrix injury. In severe cases, there might be segmental loss of cartilage. Macromolecules synthesized by chondrocytes are inadequate to fill the gaps caused by injuries. By times, OA start to set in causing chronic pain and instability. MRI is the only imaging of choice that able to provide structural details as well as biochemical information about the articular cartilage. Moreover, it would be desirable for MRI to provide an evaluation of the underlying cartilage physiology including providing information about the status of prostaglandins (PGs) and collagen matrices. T2 mapping is straightforward to perform and is sensitive to changes in collagen as well as water content, but less sensitive in detection of early degeneration. A retrospective and prospective cross sectional study using secondary and primary data to provide information on the value of T2 mapping of knee articular cartilage (medial and lateral compartment) in asymptomatic young adult and its association with gender, age and body mass index was carried out over a period of 2 years from December 2018 to December 2020. The data was then post processed with T2 mapping programming via Matlab R2019b version and further analysed with SPSS version 26. Overall, we has shown that female has slightly higher mean T2 value (49.1731ms to 51.9192ms) as compared to male population (48.4147ms to 49.4647ms) out of 30 volunteers recruited. We concluded that as we age, the T2 value increases which signify the occurrence of OA has set in slowly. In our study, T2 value increases as BMI increase as well. With 3 independent variables tested, our result were consistent with previous studies even though there was no strong association ( p > 0.05) obtained.
format	Thesis
qualification_level	Master's degree
author	Soo, Tze Hui
author_facet	Soo, Tze Hui
author_sort	Soo, Tze Hui
title	Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_short	Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_full	Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_fullStr	Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_full_unstemmed	Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_sort	association of t2 mapping of knee cartilage with age, gender & bmi among young adults attending pusat pengimejan diagnostik nucklear (ppdn), universiti putra malaysia
granting_institution	Universiti Putra Malaysia
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf
_version_	1747813824381059072

Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia

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