Effect of ruxolitinib supplementation in enhancing neurogenesis via gliogenesis suppression in foetal mouse brain development
JAK-STAT pathway is important in regulating gliogenesis in the brain. Dysregulation of this pathway leads to abnormality in brain development as seen in Down syndrome individuals’ predominantly low initial neuron-glia ratio in early infancy. Thus, suppression of JAK-STAT pathway would be advantageou...
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| Format: | Thesis |
| Language: | English |
| Published: |
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/98051/1/FPSK%28m%29%202020%2045%20UPMIR.pdf |
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