$Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.$

Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.

Diabetic patients are exposing to high probability of chronic wound and increase risk of wound infection. Metformin is recognised as the standard drug for diabetes treatment to lower both basal and postprandial plasma glucose. Past research has reported that the treatment with metformin could accele...

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Main Author:	Ting, Thing Min
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Diabetes Wound healing
Online Access:	http://psasir.upm.edu.my/id/eprint/99427/1/FSPP%202022%202.pdf
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id	my-upm-ir.99427
record_format	uketd_dc
spelling	my-upm-ir.994272023-04-05T23:53:38Z Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes. 2022-01 Ting, Thing Min Diabetic patients are exposing to high probability of chronic wound and increase risk of wound infection. Metformin is recognised as the standard drug for diabetes treatment to lower both basal and postprandial plasma glucose. Past research has reported that the treatment with metformin could accelerate wound healing besides regulating glucose level. However, overdose intake of metformin among patient with renal impairment may cause gastrointestinal discomforts, rare but high mortality rate in the case of lactic acidosis. This study aims to investigate a safe alternative to metformin to reduce its negative effects especially on diabetic subject. Tocotrienols Rich Fraction (TRF), a natural phytonutrient extracted from Elaeis guineensis (palm) oil has been researched and found to have many health benefits and potential medicinal effects. The potency of TRF extracted from palm oil in wound healing and diabetes management was investigated using Streptozotocin (STZ)-induced diabetes Sprague Dawley rat model. Two 6 mm full thickness excisions were created utilizing the sterile 6 mm punch biopsies on diabetic rats. A 400 mg/kg dosage of TRF per day was supplemented through oral gavage for 10 days. The wound closure rate, platelet derived growth factor-BB (PDGFBB) content, malondialdehyde (MDA) content, blood glucose level and body weight of the rats were monitored for a period of 10 days after wound creation. The results showed that TRF was comparable to metformin in stabilizing blood glucose, and stabilized the body weights of the diabetic rats suitable for diabetes use. TRF treatment as well as metformin treatment up-regulated the PDGF-BB in the blood on Day 2 of wound creation and 100% dry wound contraction at Day 10; indicated the non-delayed of growth factor at initial stage and total clean wound closure. TRF treated group detected significantly lower MDA content compared to metformin treated group. This shows TRF may have greater potency than metformin in reducing lipid peroxidation and promote better wound healing. Further analysis on the impact of TRF in modulating immune response in wound healing is recommended. Diabetes Wound healing 2022-01 Thesis http://psasir.upm.edu.my/id/eprint/99427/ http://psasir.upm.edu.my/id/eprint/99427/1/FSPP%202022%202.pdf text en public masters Universiti Putra Malaysia Diabetes Wound healing
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Diabetes Wound healing
spellingShingle	Diabetes Wound healing Ting, Thing Min Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
description	Diabetic patients are exposing to high probability of chronic wound and increase risk of wound infection. Metformin is recognised as the standard drug for diabetes treatment to lower both basal and postprandial plasma glucose. Past research has reported that the treatment with metformin could accelerate wound healing besides regulating glucose level. However, overdose intake of metformin among patient with renal impairment may cause gastrointestinal discomforts, rare but high mortality rate in the case of lactic acidosis. This study aims to investigate a safe alternative to metformin to reduce its negative effects especially on diabetic subject. Tocotrienols Rich Fraction (TRF), a natural phytonutrient extracted from Elaeis guineensis (palm) oil has been researched and found to have many health benefits and potential medicinal effects. The potency of TRF extracted from palm oil in wound healing and diabetes management was investigated using Streptozotocin (STZ)-induced diabetes Sprague Dawley rat model. Two 6 mm full thickness excisions were created utilizing the sterile 6 mm punch biopsies on diabetic rats. A 400 mg/kg dosage of TRF per day was supplemented through oral gavage for 10 days. The wound closure rate, platelet derived growth factor-BB (PDGFBB) content, malondialdehyde (MDA) content, blood glucose level and body weight of the rats were monitored for a period of 10 days after wound creation. The results showed that TRF was comparable to metformin in stabilizing blood glucose, and stabilized the body weights of the diabetic rats suitable for diabetes use. TRF treatment as well as metformin treatment up-regulated the PDGF-BB in the blood on Day 2 of wound creation and 100% dry wound contraction at Day 10; indicated the non-delayed of growth factor at initial stage and total clean wound closure. TRF treated group detected significantly lower MDA content compared to metformin treated group. This shows TRF may have greater potency than metformin in reducing lipid peroxidation and promote better wound healing. Further analysis on the impact of TRF in modulating immune response in wound healing is recommended.
format	Thesis
qualification_level	Master's degree
author	Ting, Thing Min
author_facet	Ting, Thing Min
author_sort	Ting, Thing Min
title	Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
title_short	Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
title_full	Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
title_fullStr	Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
title_full_unstemmed	Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.
title_sort	tocotrienols rich fraction from palm oil (elaeis guineesis jacq.) as potential agent for diabetes.
granting_institution	Universiti Putra Malaysia
publishDate	2022
url	http://psasir.upm.edu.my/id/eprint/99427/1/FSPP%202022%202.pdf
_version_	1776100332703580160

Tocotrienols rich fraction from palm oil (Elaeis guineesis Jacq.) as potential agent for diabetes.

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