Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action

Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycae...

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Main Author:	Tri, Widyawati
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf
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id	my-usm-ep.30395
record_format	uketd_dc
spelling	my-usm-ep.303952019-04-12T05:25:56Z Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action 2015 Tri, Widyawati RS1-441 Pharmacy and materia medica Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycaemic test), inhibited the rise of BGL of intraperitoneally glucose- loaded rats (glucose tolerance test) and lowered BGL of streptozotocin-induced diabetic rats. Dried powdered S. polyanthum leaves were extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE). In diabetic rats, single-dose administration of the extracts showed that only ME reduced BGL. However, upon repeated-dose administration for 6 days both PEE and ME reduced BGL significantly. Therefore, liquid-liquid partition was used to fractionate ME into the following fractions: chloroform (CF), ethyl acetate (EAF), n-butanol (n-BF) and water (WF). Repeated administration of CF and WF decreased BGL of diabetic rats. CF was shaken with n-hexane to yield an undissolved fraction (SF-1) and a dissolved fraction (SF-2). 2015 Thesis http://eprints.usm.my/30395/ http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Tri, Widyawati Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
description	Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycaemic test), inhibited the rise of BGL of intraperitoneally glucose- loaded rats (glucose tolerance test) and lowered BGL of streptozotocin-induced diabetic rats. Dried powdered S. polyanthum leaves were extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE). In diabetic rats, single-dose administration of the extracts showed that only ME reduced BGL. However, upon repeated-dose administration for 6 days both PEE and ME reduced BGL significantly. Therefore, liquid-liquid partition was used to fractionate ME into the following fractions: chloroform (CF), ethyl acetate (EAF), n-butanol (n-BF) and water (WF). Repeated administration of CF and WF decreased BGL of diabetic rats. CF was shaken with n-hexane to yield an undissolved fraction (SF-1) and a dissolved fraction (SF-2).
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Tri, Widyawati
author_facet	Tri, Widyawati
author_sort	Tri, Widyawati
title	Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
title_short	Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
title_full	Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
title_fullStr	Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
title_full_unstemmed	Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
title_sort	anti-diabetic activity-guided studies of syzygium polyanthum (wight) leaf extracts and elucidation of their mechanisms of action
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate	2015
url	http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf
_version_	1747820327689256960

Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action

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