The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite

Hydroxyapatite (HA) as a ceramic material is widely used for orthopaedic and dental implants, since this biomaterial has ability to stimulate osteoblast functions in vitro and in vivo. However, the exact mechanism by which HA accelerates osteoblast function, thereby stimulating rapid bone formati...

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Main Author:	Sugiatno, Erwan
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/30469/1/ERWAN_SUGIATNO.pdf
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id	my-usm-ep.30469
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spelling	my-usm-ep.304692017-05-24T01:15:45Z The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite 2006-04 Sugiatno, Erwan RK1-715 Dentistry Hydroxyapatite (HA) as a ceramic material is widely used for orthopaedic and dental implants, since this biomaterial has ability to stimulate osteoblast functions in vitro and in vivo. However, the exact mechanism by which HA accelerates osteoblast function, thereby stimulating rapid bone formation, remains far from clear. It is well known that bone formation is tightly regulated by nitric oxide (NO) via its effects on osteoblast and osteoclast function. Therefore, the overall aim of the present studies was to elucidate the possible regulation ofNO in HA-stimulated HOS cell proliferation. The present study used a human osteoblast cell line (HOS cells), since this cell line is known to mimic the functions of normal human osteoblasts, thereby representing the biological response of normal osteoblasts in humans. Hidroksiapatit (HA), yang merupakan bahan seramik, digunakan dengan meluas didalam bidang ortopedik dan implantologi pergigian kerana keupayaannya untuk meyebabkan stimulasi fungsi 'in vitro' dan 'in vivo' sel osteoblas. Walaubagaimanapun, mekanisma dimana HA menggalakkan fungsi sel osteoblas, iaitu pembentukkan tulang masih tidak jelas. Nitrik oksida (NO) meregulasi pembentukkan tulang melalui kesannya terhadap fungsi sel osteoblas dan osteoklas. Maka, tujuan keseluruhan kajian terkini adalah untuk mengetahui kemungkina:n regulasi NO tethadap proliferasi sel HOS yang telah distimulasi oleh HA. Kajian ini telah meggunakan sel induk osteoblas manusia (sel HOS) kerana sel-sel ini dapat mewakili respons biologikal sel osteoblas normal manusia. 2006-04 Thesis http://eprints.usm.my/30469/ http://eprints.usm.my/30469/1/ERWAN_SUGIATNO.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RK1-715 Dentistry
spellingShingle	RK1-715 Dentistry Sugiatno, Erwan The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
description	Hydroxyapatite (HA) as a ceramic material is widely used for orthopaedic and dental implants, since this biomaterial has ability to stimulate osteoblast functions in vitro and in vivo. However, the exact mechanism by which HA accelerates osteoblast function, thereby stimulating rapid bone formation, remains far from clear. It is well known that bone formation is tightly regulated by nitric oxide (NO) via its effects on osteoblast and osteoclast function. Therefore, the overall aim of the present studies was to elucidate the possible regulation ofNO in HA-stimulated HOS cell proliferation. The present study used a human osteoblast cell line (HOS cells), since this cell line is known to mimic the functions of normal human osteoblasts, thereby representing the biological response of normal osteoblasts in humans. Hidroksiapatit (HA), yang merupakan bahan seramik, digunakan dengan meluas didalam bidang ortopedik dan implantologi pergigian kerana keupayaannya untuk meyebabkan stimulasi fungsi 'in vitro' dan 'in vivo' sel osteoblas. Walaubagaimanapun, mekanisma dimana HA menggalakkan fungsi sel osteoblas, iaitu pembentukkan tulang masih tidak jelas. Nitrik oksida (NO) meregulasi pembentukkan tulang melalui kesannya terhadap fungsi sel osteoblas dan osteoklas. Maka, tujuan keseluruhan kajian terkini adalah untuk mengetahui kemungkina:n regulasi NO tethadap proliferasi sel HOS yang telah distimulasi oleh HA. Kajian ini telah meggunakan sel induk osteoblas manusia (sel HOS) kerana sel-sel ini dapat mewakili respons biologikal sel osteoblas normal manusia.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Sugiatno, Erwan
author_facet	Sugiatno, Erwan
author_sort	Sugiatno, Erwan
title	The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
title_short	The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
title_full	The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
title_fullStr	The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
title_full_unstemmed	The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite
title_sort	role of nitric oxide on the proliferation of human osteoblasts (hos cells) stimulated with hydroxyapatite
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2006
url	http://eprints.usm.my/30469/1/ERWAN_SUGIATNO.pdf
_version_	1747820342305357824

The Role Of Nitric Oxide On The Proliferation Of Human Osteoblasts (Hos Cells) Stimulated With Hydroxyapatite

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