Perkembangan Kaedah Pra-Klinlkal Asid Artesunik, Satu Terbitan Artemisinin Yang Baru
Artesunic acid, a derivative of artemisinin has proven to be rapidly effective and safe in the treatment of malaria. Artesunic acid has been formulated for parenteral and oral use and has recently become available as suppositories for rectal administration. Artesunic acid and it's active met...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2002
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| Subjects: | |
| Online Access: | http://eprints.usm.my/30592/1/KATHIRESAN_A.L_V.SATHASIVAM.pdf |
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| Summary: | Artesunic acid, a derivative of artemisinin has proven to be rapidly effective and safe in the
treatment of malaria. Artesunic acid has been formulated for parenteral and oral use and
has recently become available as suppositories for rectal administration. Artesunic acid and
it's active metabolite, dihydroartemisinin used in all these studies was characterized using
infrared and nuclear magnetic resonance. The purity was determined by high performance
liquid chromatography coupled with an electrochemical detector.
Asid artesunik merupakan terbitan artemisinin yang berkesan dan selamat digunakan
untuk merawat kes-kes malaria. Asid artesunik wluud dalam formulasi parenteral dan
oral, kini dibentuk secara suppositori untuk pemberian secara rektal. Sehingga kini, masih
tiada kaedah pelarutan secara rasmi bagi suppositori asid artesunik. Kaedah inframerah
dan resonans magnetik nuklear telah digunakan untuk pencirian asid artesunik dan
metobolit aktifnya, dihidroartemisinin.. Ketulenan sebatian-sebatian tersebut telah
ditentukan menggunakan kromatografi cecair prestasi tinggi yang dilengkapi dengan
pengesan elektrokimia. |
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