Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form

Satisfactory spherical pellets were successfully· prepared by the process of extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as pellet-forming material. Nonetheless, the preparation of acceptable round spheres is highly dependent upon the attainment of an optimal f...

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Main Author:	Lee, Bee Cheng
Format:	Thesis
Language:	English
Published:	1995
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf
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id	my-usm-ep.30616
record_format	uketd_dc
spelling	my-usm-ep.306162017-03-22T01:59:56Z Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form 1995-02 Lee, Bee Cheng RS1-441 Pharmacy and materia medica Satisfactory spherical pellets were successfully· prepared by the process of extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as pellet-forming material. Nonetheless, the preparation of acceptable round spheres is highly dependent upon the attainment of an optimal formulation suited for this mcthod or proccssillg. The earlier part of the work has revealed that the MCe pellet system containing the active ingredientdiclofenac sodium generally produced strongly bonded spheroids which remained intact throughout the dissolution test. It may thus be postulated that the pellets behaved as an inert matrix system. Pelet~pelet yang berbentuk sfera telah berjaya disediakan melalui proses ekstrusi/sferonisasi dengan menggunakan mikrokristalin selulosa sebagai bahan pembentuk pelet. Walau bagaimanapun, penyediaan sfera yang baik sang at hc:rr~,HlruJlE kerada remerolehan suatu formulasi optimum yang padan akan proses tersebut. Kajian awal telah menunjukkan bahawa sistem pelet mikrokristalin selulosa yang mengandungi ramuan aktif diclofenac sodium, pada amnya menghasilkan sferoid yang mempunyai ikatan kuat sehingga bentuknya masih kekal semasa proses pemelarutan. Dengan ini, boleh dikatakan bahawa pelet tersebut bertindak sebagai sistem matriks lengai. 1995-02 Thesis http://eprints.usm.my/30616/ http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Lee, Bee Cheng Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
description	Satisfactory spherical pellets were successfully· prepared by the process of extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as pellet-forming material. Nonetheless, the preparation of acceptable round spheres is highly dependent upon the attainment of an optimal formulation suited for this mcthod or proccssillg. The earlier part of the work has revealed that the MCe pellet system containing the active ingredientdiclofenac sodium generally produced strongly bonded spheroids which remained intact throughout the dissolution test. It may thus be postulated that the pellets behaved as an inert matrix system. Pelet~pelet yang berbentuk sfera telah berjaya disediakan melalui proses ekstrusi/sferonisasi dengan menggunakan mikrokristalin selulosa sebagai bahan pembentuk pelet. Walau bagaimanapun, penyediaan sfera yang baik sang at hc:rr~,HlruJlE kerada remerolehan suatu formulasi optimum yang padan akan proses tersebut. Kajian awal telah menunjukkan bahawa sistem pelet mikrokristalin selulosa yang mengandungi ramuan aktif diclofenac sodium, pada amnya menghasilkan sferoid yang mempunyai ikatan kuat sehingga bentuknya masih kekal semasa proses pemelarutan. Dengan ini, boleh dikatakan bahawa pelet tersebut bertindak sebagai sistem matriks lengai.
format	Thesis
qualification_level	Master's degree
author	Lee, Bee Cheng
author_facet	Lee, Bee Cheng
author_sort	Lee, Bee Cheng
title	Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
title_short	Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
title_full	Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
title_fullStr	Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
title_full_unstemmed	Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
title_sort	evaluation of spheronized pellets as potential matrix sustained release dosage form
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	1995
url	http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf
_version_	1747820369452990464

Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form

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