Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism

Terdapat pelbagai bentuk CYP2A6. la memetabolismekan nikotina, kotinina dan sesetengah pro-karsinogen serta drug. Variasi dalam aiel CYP2A6 boleh mengurangkan risiko untuk merokok dan frekuensi bagi 'PM' adalah lebih rendah dikalangan penduduk Barat (Caucasion) berbanding penduduk Asia....

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Main Author:	Musa, Nurfadhlina
Format:	Thesis
Language:	English
Published:	2006
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/31034/1/NURFADHLINA_BINTI_MUSA.pdf
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id	my-usm-ep.31034
record_format	uketd_dc
spelling	my-usm-ep.310342017-05-15T04:43:38Z Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism 2006 Musa, Nurfadhlina R735-854 Medical education. Medical schools. Research Terdapat pelbagai bentuk CYP2A6. la memetabolismekan nikotina, kotinina dan sesetengah pro-karsinogen serta drug. Variasi dalam aiel CYP2A6 boleh mengurangkan risiko untuk merokok dan frekuensi bagi 'PM' adalah lebih rendah dikalangan penduduk Barat (Caucasion) berbanding penduduk Asia. Objektif kajian kami adalah untuk membangunkan kaedah genetik molekul dan analitikal bagi mengkaji kepelbagaian CYP2A6 di Malaysia. Subjek terdiri daripada dewasa yang sihat berketurunan Melayu, Cina dan India yang telah bersetuju menyertai kajian ini. DNA yang telah diesktrak daripada darah menggunakan kaedah 'saltingout' seterusnya digunakan untuk mengesan genotip CYP2A6 melalui kaedah PCR. CYP2A6 is polymorphic. It metabolizes nicotine, cotinine, several pro-carcinogens and drugs. Variant CYP2A6 alleles reduced risks for smoking and Caucasian have lower frequencies for the PM phenotype than Asians. The objective of our study was to develop analytical and molecular genetic methods for studying CYP2A6 polymorphism in Malaysia. Subjects were healthy adult Malays, Chinese and Indians who gave informed consents. DNA was extiacted from blood using salting out procedures and subjected to PCR-genotyping for CYP2A6. 2006 Thesis http://eprints.usm.my/31034/ http://eprints.usm.my/31034/1/NURFADHLINA_BINTI_MUSA.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Musa, Nurfadhlina Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
description	Terdapat pelbagai bentuk CYP2A6. la memetabolismekan nikotina, kotinina dan sesetengah pro-karsinogen serta drug. Variasi dalam aiel CYP2A6 boleh mengurangkan risiko untuk merokok dan frekuensi bagi 'PM' adalah lebih rendah dikalangan penduduk Barat (Caucasion) berbanding penduduk Asia. Objektif kajian kami adalah untuk membangunkan kaedah genetik molekul dan analitikal bagi mengkaji kepelbagaian CYP2A6 di Malaysia. Subjek terdiri daripada dewasa yang sihat berketurunan Melayu, Cina dan India yang telah bersetuju menyertai kajian ini. DNA yang telah diesktrak daripada darah menggunakan kaedah 'saltingout' seterusnya digunakan untuk mengesan genotip CYP2A6 melalui kaedah PCR. CYP2A6 is polymorphic. It metabolizes nicotine, cotinine, several pro-carcinogens and drugs. Variant CYP2A6 alleles reduced risks for smoking and Caucasian have lower frequencies for the PM phenotype than Asians. The objective of our study was to develop analytical and molecular genetic methods for studying CYP2A6 polymorphism in Malaysia. Subjects were healthy adult Malays, Chinese and Indians who gave informed consents. DNA was extiacted from blood using salting out procedures and subjected to PCR-genotyping for CYP2A6.
format	Thesis
qualification_level	Master's degree
author	Musa, Nurfadhlina
author_facet	Musa, Nurfadhlina
author_sort	Musa, Nurfadhlina
title	Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
title_short	Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
title_full	Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
title_fullStr	Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
title_full_unstemmed	Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
title_sort	genetic polymorphisms in the cyp2a6: implications for inter-individual differences in nicotine metabolism
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2006
url	http://eprints.usm.my/31034/1/NURFADHLINA_BINTI_MUSA.pdf
_version_	1747820391392346112

Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism

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