Cell-Penetrating Antibodies For Targeting Hiv-1 P24 Capsid Protein

Protein kapsid p24 memainkan peranan yang penting dalam peringkat awal dan akhir replikasi HIV. Justeru, kapsid HIV-1 dianggap sebagai sasaran penting dalam pembangunan ubat terapi baharu untuk merawat HIV/AIDS. The capsid protein plays seminal roles in both early and late stages of the HIV r...

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Bibliographic Details
Main Author: Teow , Sin Yeang
Format: Thesis
Language:English
Published: 2015
Subjects:
Online Access:http://eprints.usm.my/31512/1/TEAW_SIN_YEANG.pdf
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Summary:Protein kapsid p24 memainkan peranan yang penting dalam peringkat awal dan akhir replikasi HIV. Justeru, kapsid HIV-1 dianggap sebagai sasaran penting dalam pembangunan ubat terapi baharu untuk merawat HIV/AIDS. The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells.