In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood

Dicranopteris linearis (Burm.) Underwood merupakan sejenis paku-pakis menjalar tanah yang digunakan secara tradisional untuk merawat pelbagai penyakit kulit seperti bisul, ulser dan luka luaran. Sehingga kini, tiada kajian saintifik yang dijalankan secara sistematik untuk menilai kegunaan etnofar...

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Main Author:	Ponnusamy, Yasodha
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/31589/1/YASODHA_PONNUSAMY_24.pdf
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id	my-usm-ep.31589
record_format	uketd_dc
spelling	my-usm-ep.315892019-04-12T05:25:23Z In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood 2016-03 Ponnusamy, Yasodha RM300-666 Drugs and their actions Dicranopteris linearis (Burm.) Underwood merupakan sejenis paku-pakis menjalar tanah yang digunakan secara tradisional untuk merawat pelbagai penyakit kulit seperti bisul, ulser dan luka luaran. Sehingga kini, tiada kajian saintifik yang dijalankan secara sistematik untuk menilai kegunaan etnofarmakologikal D. linearis untuk mempercepatkan penyembuhan luka.Dalam kajian ini, ekstrak MeOH daripada D. linearis telah diperkaya dengan sebatian bioaktif dengan menggunakan kaedah berpandukan bioaktiviti. Salah satu fraksi ekstrak (F5) yang diperoleh telah didapati memiliki aktiviti antioksidan dan aktiviti antibakteria yang signifikan terhadap S. aureus dan P. aeruginosa. Analisis telah dilanjutkan untuk mengenal pasti kompoun dalam fraksi aktif ini. Pemencilan sebatian telah dijalankan dengan menggunakan gabungan teknik kromatokrafi.gel silica fasa terbalik dan normal. Dicranopteris linearis (Burm.)Underwood is a ground creeping fern used traditionally to treat various skin related ailments, such as boils, ulcers and external wounds. To date, no scientific studies have been carried out to evaluate its ethnopharmacological use in wound infection in a systematic manner. In the present study, the MeOH extract of D. linearis was fractionated with the bioactive constituents following a bioactivity-guided approach. A fraction (F5) of the extract was obtained and it was found to possess significant antioxidant and antibacterial activity against S. aureus and P. aeruginosa. Analysis was further carried out to identify the chemical constituents of this active fraction. Isolation of the major constituents was carried out using a combination of reversed-phase and normal-phase silica gel chromatographic techniques. 2016-03 Thesis http://eprints.usm.my/31589/ http://eprints.usm.my/31589/1/YASODHA_PONNUSAMY_24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-Ubatan (Centre for Drug Research)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Ponnusamy, Yasodha In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
description	Dicranopteris linearis (Burm.) Underwood merupakan sejenis paku-pakis menjalar tanah yang digunakan secara tradisional untuk merawat pelbagai penyakit kulit seperti bisul, ulser dan luka luaran. Sehingga kini, tiada kajian saintifik yang dijalankan secara sistematik untuk menilai kegunaan etnofarmakologikal D. linearis untuk mempercepatkan penyembuhan luka.Dalam kajian ini, ekstrak MeOH daripada D. linearis telah diperkaya dengan sebatian bioaktif dengan menggunakan kaedah berpandukan bioaktiviti. Salah satu fraksi ekstrak (F5) yang diperoleh telah didapati memiliki aktiviti antioksidan dan aktiviti antibakteria yang signifikan terhadap S. aureus dan P. aeruginosa. Analisis telah dilanjutkan untuk mengenal pasti kompoun dalam fraksi aktif ini. Pemencilan sebatian telah dijalankan dengan menggunakan gabungan teknik kromatokrafi.gel silica fasa terbalik dan normal. Dicranopteris linearis (Burm.)Underwood is a ground creeping fern used traditionally to treat various skin related ailments, such as boils, ulcers and external wounds. To date, no scientific studies have been carried out to evaluate its ethnopharmacological use in wound infection in a systematic manner. In the present study, the MeOH extract of D. linearis was fractionated with the bioactive constituents following a bioactivity-guided approach. A fraction (F5) of the extract was obtained and it was found to possess significant antioxidant and antibacterial activity against S. aureus and P. aeruginosa. Analysis was further carried out to identify the chemical constituents of this active fraction. Isolation of the major constituents was carried out using a combination of reversed-phase and normal-phase silica gel chromatographic techniques.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ponnusamy, Yasodha
author_facet	Ponnusamy, Yasodha
author_sort	Ponnusamy, Yasodha
title	In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
title_short	In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
title_full	In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
title_fullStr	In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
title_full_unstemmed	In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood
title_sort	in vitro antibacterial and wound healing properties of a standardized polyphenols-rich fraction of dicranopteris linearis (burm.) underwood
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah dan Ubat-Ubatan (Centre for Drug Research)
publishDate	2016
url	http://eprints.usm.my/31589/1/YASODHA_PONNUSAMY_24.pdf
_version_	1747820457473605632

In Vitro Antibacterial And Wound Healing Properties Of A Standardized Polyphenols-Rich Fraction Of Dicranopteris Linearis (BURM.) Underwood

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