The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes

Kebangkitan penggunaan ubat-ubatan herba di seluruh dunia, dan penggunaan bersama drug konvensional dan terapi tradisional telah menjadi kebiasaan. Gynura procumbens ialah herba malar hijau yang lazimnya dimakan secara mentah atau diminum sebagai teh di Malaysia. Walaupun pelbagai kajian mengenai ak...

Full description

Saved in:

Bibliographic Details
Main Author:	Afandi, Atiqah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/31622/1/ATIQAH_AFANDI.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.31622
record_format	uketd_dc
spelling	my-usm-ep.316222019-04-12T05:25:42Z The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes 2015-07 Afandi, Atiqah R5-920 Medicine (General) Kebangkitan penggunaan ubat-ubatan herba di seluruh dunia, dan penggunaan bersama drug konvensional dan terapi tradisional telah menjadi kebiasaan. Gynura procumbens ialah herba malar hijau yang lazimnya dimakan secara mentah atau diminum sebagai teh di Malaysia. Walaupun pelbagai kajian mengenai aktiviti farmakologi Gynura procumbens telah dijalankan, interaksi di antara herba ini dengan enzim metabolisme drug masih tidak diketahui. Ini adalah kajian pertama berkaitan dengan modulasi ekstrak Gynura procumbens terhadap enzim metabolisme drug. Pengekstrakan daun Gynura procumbens dengan air, etanol dan metanol masing-masing menghasilkan peratusan hasil sebanyak 27.50%, 7.80% dan 4.20%. Kuantifikasi dua sebatian penanda kaempferol-3-O-rutinosida dan astragalin di dalam setiap ekstrak adalah berjaya kecuali ekstrak akueus Gynura procumbens. Setiap ekstrak etanol dan metanol masing-masing mengandungi kaempferol-3-O-rutinosida dan astagalin sebanyak 1.60% dan 1.79% dan 2.33% dan 3.83%. Resurgence in the use of herbal medicines worldwide and the co-use of conventional drug and traditional therapies is becoming more common. Gynura procumbens is an evergreen herb that has been commonly eaten raw or drink as tea in Malaysia. Despite various studies conducted on the pharmacological activities of Gynura procumbens, the interaction between this herb with drug metabolizing enzymes is still unknown. This is the first study regarding the modulation of Gynura procumbens extracts towards drug metabolizing enzymes. Extraction of Gynura procumbens leaves with water, ethanol and methanol produced a percentage of yields of 27.50%, 7.80% and 4.20% respectively. Quantification of two marker compounds kaempferol-3-O-rutinoside and astragalin in each extracts is successful except for the aqueous extract of Gynura procumbens. Each ethanol and methanol extracts contain 1.60% and 1.79% and 2.33% and 3.83% of kaempferol-3-O-rutinoside and astragalin respectively. 2015-07 Thesis http://eprints.usm.my/31622/ http://eprints.usm.my/31622/1/ATIQAH_AFANDI.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah & Ubat-ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Afandi, Atiqah The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
description	Kebangkitan penggunaan ubat-ubatan herba di seluruh dunia, dan penggunaan bersama drug konvensional dan terapi tradisional telah menjadi kebiasaan. Gynura procumbens ialah herba malar hijau yang lazimnya dimakan secara mentah atau diminum sebagai teh di Malaysia. Walaupun pelbagai kajian mengenai aktiviti farmakologi Gynura procumbens telah dijalankan, interaksi di antara herba ini dengan enzim metabolisme drug masih tidak diketahui. Ini adalah kajian pertama berkaitan dengan modulasi ekstrak Gynura procumbens terhadap enzim metabolisme drug. Pengekstrakan daun Gynura procumbens dengan air, etanol dan metanol masing-masing menghasilkan peratusan hasil sebanyak 27.50%, 7.80% dan 4.20%. Kuantifikasi dua sebatian penanda kaempferol-3-O-rutinosida dan astragalin di dalam setiap ekstrak adalah berjaya kecuali ekstrak akueus Gynura procumbens. Setiap ekstrak etanol dan metanol masing-masing mengandungi kaempferol-3-O-rutinosida dan astagalin sebanyak 1.60% dan 1.79% dan 2.33% dan 3.83%. Resurgence in the use of herbal medicines worldwide and the co-use of conventional drug and traditional therapies is becoming more common. Gynura procumbens is an evergreen herb that has been commonly eaten raw or drink as tea in Malaysia. Despite various studies conducted on the pharmacological activities of Gynura procumbens, the interaction between this herb with drug metabolizing enzymes is still unknown. This is the first study regarding the modulation of Gynura procumbens extracts towards drug metabolizing enzymes. Extraction of Gynura procumbens leaves with water, ethanol and methanol produced a percentage of yields of 27.50%, 7.80% and 4.20% respectively. Quantification of two marker compounds kaempferol-3-O-rutinoside and astragalin in each extracts is successful except for the aqueous extract of Gynura procumbens. Each ethanol and methanol extracts contain 1.60% and 1.79% and 2.33% and 3.83% of kaempferol-3-O-rutinoside and astragalin respectively.
format	Thesis
qualification_level	Master's degree
author	Afandi, Atiqah
author_facet	Afandi, Atiqah
author_sort	Afandi, Atiqah
title	The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
title_short	The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
title_full	The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
title_fullStr	The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
title_full_unstemmed	The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes
title_sort	effects of gynura procumbens extracts on drug metabolizing enzymes
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah & Ubat-ubatan
publishDate	2015
url	http://eprints.usm.my/31622/1/ATIQAH_AFANDI.pdf
_version_	1747820465300176896

The Effects Of Gynura Procumbens Extracts On Drug Metabolizing Enzymes

Similar Items