Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats

Mitragyna speciose Korth (Rubiaceae) merupakan sejenis pokok yang berasal dari bahagian utara Semenanjung Malaysia dan selatan Thailand. Alkaloid utama dalam tumbuhan ini, iaitu mitraginina (MG), telah dilaporkan bertanggungjawab terhadap kebanyakan sifat farmakologinya. Dos MG yang digunakan dalam...

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Main Author:	Imad Hazim Al Ganaby, Ammar
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/31849/1/AMMAR_IMAD_HAZIM_AL_GANABY_24%28NN%29.pdf
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id	my-usm-ep.31849
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spelling	my-usm-ep.318492019-04-12T05:25:22Z Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats 2016-03 Imad Hazim Al Ganaby, Ammar RM300-666 Drugs and their actions Mitragyna speciose Korth (Rubiaceae) merupakan sejenis pokok yang berasal dari bahagian utara Semenanjung Malaysia dan selatan Thailand. Alkaloid utama dalam tumbuhan ini, iaitu mitraginina (MG), telah dilaporkan bertanggungjawab terhadap kebanyakan sifat farmakologinya. Dos MG yang digunakan dalam kebanyakan kajian farmakologi mempunyai perbezaan yang ketara, sekaligus menggambarkan bahawa cadangan pemilihan dos dalam pelbagai kajian yang lepas adalah berkemungkinan dijalankan secara empirikal iaitu tanpa asas saintifik yang sewajarnya. Walaubagaimanapun, kajian semasa mendedahkan bahawa terdapat variasi dos yang besar telah digunakan. Hal ini disebabkan oleh sifat fizikokimia MG tetapi variasi dos tersebut tidak pula terbatas hanya kepada sifat fizikokimia MG. Disebabkan penilaian farmakokinetik merupakan komponen penting dalam proses pemilihan dos, maka usaha diperlukan untuk menentukan sifat farmakokinetik MG seperti perkadaran dos, akumulasi drug, ikatan protein plasma dan taburan tisu dalam tikus. Mitragyna speciosa Korth (Rubiaceae) is an indigenous tree found in the Northern Malaysian Peninsula and in Southern Thailand. The principal alkaloid of this plant, Mitragynine (MG), has been reported to be responsible for most of its pharmacological properties. Doses of MG employed in most pharmacological studies vary greatly, which suggests that the selection of these doses was possibly carried out empirically without proper scientific basis. However, recent studies revealed that large dose variation was due but not limited, to MG physicochemical properties. Since pharmacokinetic evaluation is an essential component in the dose selection process, work was undertaken to determine MG pharmacokinetic properties such as dose proportionality, accumulation, plasma protein binding and tissue distribution in rats. 2016-03 Thesis http://eprints.usm.my/31849/ http://eprints.usm.my/31849/1/AMMAR_IMAD_HAZIM_AL_GANABY_24%28NN%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-Ubatan (Centre for Drug Research)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Imad Hazim Al Ganaby, Ammar Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
description	Mitragyna speciose Korth (Rubiaceae) merupakan sejenis pokok yang berasal dari bahagian utara Semenanjung Malaysia dan selatan Thailand. Alkaloid utama dalam tumbuhan ini, iaitu mitraginina (MG), telah dilaporkan bertanggungjawab terhadap kebanyakan sifat farmakologinya. Dos MG yang digunakan dalam kebanyakan kajian farmakologi mempunyai perbezaan yang ketara, sekaligus menggambarkan bahawa cadangan pemilihan dos dalam pelbagai kajian yang lepas adalah berkemungkinan dijalankan secara empirikal iaitu tanpa asas saintifik yang sewajarnya. Walaubagaimanapun, kajian semasa mendedahkan bahawa terdapat variasi dos yang besar telah digunakan. Hal ini disebabkan oleh sifat fizikokimia MG tetapi variasi dos tersebut tidak pula terbatas hanya kepada sifat fizikokimia MG. Disebabkan penilaian farmakokinetik merupakan komponen penting dalam proses pemilihan dos, maka usaha diperlukan untuk menentukan sifat farmakokinetik MG seperti perkadaran dos, akumulasi drug, ikatan protein plasma dan taburan tisu dalam tikus. Mitragyna speciosa Korth (Rubiaceae) is an indigenous tree found in the Northern Malaysian Peninsula and in Southern Thailand. The principal alkaloid of this plant, Mitragynine (MG), has been reported to be responsible for most of its pharmacological properties. Doses of MG employed in most pharmacological studies vary greatly, which suggests that the selection of these doses was possibly carried out empirically without proper scientific basis. However, recent studies revealed that large dose variation was due but not limited, to MG physicochemical properties. Since pharmacokinetic evaluation is an essential component in the dose selection process, work was undertaken to determine MG pharmacokinetic properties such as dose proportionality, accumulation, plasma protein binding and tissue distribution in rats.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Imad Hazim Al Ganaby, Ammar
author_facet	Imad Hazim Al Ganaby, Ammar
author_sort	Imad Hazim Al Ganaby, Ammar
title	Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
title_short	Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
title_full	Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
title_fullStr	Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
title_full_unstemmed	Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats
title_sort	pharmacokinetics and investigation of the anxiolytic-like effect of mitragynine in rats
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah dan Ubat-Ubatan (Centre for Drug Research)
publishDate	2016
url	http://eprints.usm.my/31849/1/AMMAR_IMAD_HAZIM_AL_GANABY_24%28NN%29.pdf
_version_	1747820497048961024

Pharmacokinetics And Investigation Of The Anxiolytic-Like Effect Of Mitragynine In Rats

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