Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives

Thiazol, thiazolidinon, thiadiazol, fenilakrilohidrazid dan kumarin merupakan sebahagian daripada kelas sebatian heterosiklik yang mempunyai kepentingan dalam bidang perubatan dan farmakologi. Dalam kajian ini enam siri daripada 67 sebatian kumarin baru yang aktif secara biologi telah disintesis...

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Main Author:	Yusuf Zai, Samina Khan
Format:	Thesis
Language:	English
Published:	2015
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/32040/1/Samina_Khan_Yusuf_Zai.pdf
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id	my-usm-ep.32040
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spelling	my-usm-ep.320402019-04-12T05:25:43Z Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives 2015-07 Yusuf Zai, Samina Khan QD1-999 Chemistry Thiazol, thiazolidinon, thiadiazol, fenilakrilohidrazid dan kumarin merupakan sebahagian daripada kelas sebatian heterosiklik yang mempunyai kepentingan dalam bidang perubatan dan farmakologi. Dalam kajian ini enam siri daripada 67 sebatian kumarin baru yang aktif secara biologi telah disintesis dengan mencantumkan unit thiazol, thiazolidinon, thiadiazol dan fenilakrilohidrazid ke dalam rangka kumarin untuk meningkatkan kegunaannya sebagai agen terapeutik yang penting. Semua terbitan yang telah disintesis dicirikan menggunakan teknik spektroskopik seperti IR, 1D NMR (1H dan 13C) dan analisis CHN bersama LC-MS. Struktur terbitan terpilih telah dipastikan lebih dengan lanjut menggunakan teknik spektroskopik 2D NMR (COSY, HMQC dan HMBC). Di samping itu, analisis pembelauan X-Ray telah digunakan bagi mengesahkan struktur sebatian yang diperolehi adalah kristal tunggal. Struktur semua bahan permulaan yang disintesis telah disahkan dengan membandingkan data spektroskopi tersebut dengan yang telah dilaporkan dalam literatur. Sukatan takat lebur telah dijalankan kepada semua sebatian bagi memeriksa ketulenan mereka. Thiazoles, thiazolidinones, thiadiazoles, phenylacrylohydrazides and coumarins, are few of the very important classes of heterocyclic compounds having great medicinal and pharmacological importance. In the present study, six series of 67 new biologically active coumarin derived compounds have been synthesized by substituting thiazole, thiazolidinone, thiadiazole and phenylacrylohydrazide units into the coumarin core, in order to increase their use as important therapeutic agents. The structures of all the new compounds were characterized by spectroscopic techniques such as, IR, 1D NMR (1H and 13C) and CHN analysis together with LCMS. The structures of the selective compounds from each series were further confirmed by 2D NMR (COSY, HMQC and HMBC) spectroscopic techniques. In addition to this X-Ray diffraction analysis was used to confirm, the structures for those compounds obtained as single crystals. The structures of all the synthesized starting materials were confirmed by the comparison of their spectroscopic data with those already reported in literature. Melting point measurements was done for all the synthesized compounds, in order to check their purity. 2015-07 Thesis http://eprints.usm.my/32040/ http://eprints.usm.my/32040/1/Samina_Khan_Yusuf_Zai.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Yusuf Zai, Samina Khan Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
description	Thiazol, thiazolidinon, thiadiazol, fenilakrilohidrazid dan kumarin merupakan sebahagian daripada kelas sebatian heterosiklik yang mempunyai kepentingan dalam bidang perubatan dan farmakologi. Dalam kajian ini enam siri daripada 67 sebatian kumarin baru yang aktif secara biologi telah disintesis dengan mencantumkan unit thiazol, thiazolidinon, thiadiazol dan fenilakrilohidrazid ke dalam rangka kumarin untuk meningkatkan kegunaannya sebagai agen terapeutik yang penting. Semua terbitan yang telah disintesis dicirikan menggunakan teknik spektroskopik seperti IR, 1D NMR (1H dan 13C) dan analisis CHN bersama LC-MS. Struktur terbitan terpilih telah dipastikan lebih dengan lanjut menggunakan teknik spektroskopik 2D NMR (COSY, HMQC dan HMBC). Di samping itu, analisis pembelauan X-Ray telah digunakan bagi mengesahkan struktur sebatian yang diperolehi adalah kristal tunggal. Struktur semua bahan permulaan yang disintesis telah disahkan dengan membandingkan data spektroskopi tersebut dengan yang telah dilaporkan dalam literatur. Sukatan takat lebur telah dijalankan kepada semua sebatian bagi memeriksa ketulenan mereka. Thiazoles, thiazolidinones, thiadiazoles, phenylacrylohydrazides and coumarins, are few of the very important classes of heterocyclic compounds having great medicinal and pharmacological importance. In the present study, six series of 67 new biologically active coumarin derived compounds have been synthesized by substituting thiazole, thiazolidinone, thiadiazole and phenylacrylohydrazide units into the coumarin core, in order to increase their use as important therapeutic agents. The structures of all the new compounds were characterized by spectroscopic techniques such as, IR, 1D NMR (1H and 13C) and CHN analysis together with LCMS. The structures of the selective compounds from each series were further confirmed by 2D NMR (COSY, HMQC and HMBC) spectroscopic techniques. In addition to this X-Ray diffraction analysis was used to confirm, the structures for those compounds obtained as single crystals. The structures of all the synthesized starting materials were confirmed by the comparison of their spectroscopic data with those already reported in literature. Melting point measurements was done for all the synthesized compounds, in order to check their purity.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Yusuf Zai, Samina Khan
author_facet	Yusuf Zai, Samina Khan
author_sort	Yusuf Zai, Samina Khan
title	Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
title_short	Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
title_full	Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
title_fullStr	Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
title_full_unstemmed	Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives
title_sort	synthesis, characterization and microbial activity of new thiazole, thiazolidinone, thiadiazole and phenylacrylohydrazide substituted coumarin derivatives
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2015
url	http://eprints.usm.my/32040/1/Samina_Khan_Yusuf_Zai.pdf
_version_	1747820520111341568

Synthesis, Characterization And Microbial Activity Of New Thiazole, Thiazolidinone, Thiadiazole And Phenylacrylohydrazide Substituted Coumarin Derivatives

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