Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study

Satu kajian membujur kuasi eksperimen bukan rawak telah dijalankan untuk menilai keberkesanan serta keselamatan dan ketoleranan pengambilan 75mg pregabalin pos hemodialisis (pHD) sekali sehari secara lisan, bagi uremic pruritus (UP) yang resistan pada rawatan, di kalangan pesakit ESRD dalam pusat bu...

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Main Author:	Khan, Tahir Mehmood
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/32084/1/Tahir_Mehmood_Khan.pdf
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id	my-usm-ep.32084
record_format	uketd_dc
spelling	my-usm-ep.320842019-04-12T05:25:43Z Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study 2015-05 Khan, Tahir Mehmood RS1-441 Pharmacy and materia medica Satu kajian membujur kuasi eksperimen bukan rawak telah dijalankan untuk menilai keberkesanan serta keselamatan dan ketoleranan pengambilan 75mg pregabalin pos hemodialisis (pHD) sekali sehari secara lisan, bagi uremic pruritus (UP) yang resistan pada rawatan, di kalangan pesakit ESRD dalam pusat buah pinggang Aljaber, Hospital King Fahad, Alahsa Arab Saudi. Pengukuran untuk keterukan dan intensiti gatal dilakukan dengan menggunakan skala gatal-5D versi Bahasa Arab yang telah divalidasi (α = 0.847 p = 0.001, Kaiser- Meyer-Oklin value = 0.810). Pengukuran tahap selamat dan ketoleranan pada pregabalin telah dilakukan dengan menggunakan algoritma Naranjo. Model linear teritlak digunakan untuk mengukur kesan selang waktu pengambilan pregabalin. Selanjutnya, untuk menentukan perbezaan kesan pregabalin pada selang masa yang berbeza, persamaan anggaran teritlak digunakan. Akhirnya untuk pentaksiran hubungan unsur-unsur demografi dan tahap keterukan UP, simulasi Monte Carlo telah dipilih. A quasi, non-randomized longitudinal study was conducted to assess the effectiveness of 75mg pregabalin post hemodialysis (pHD) once daily orally in treatment-resistant uremic pruritus (UP), and the safety and tolerability among ESRD patients at Aljaber kidney center, King Fahad Hospital, Alahsa Saudi Arabia. Assessment for the severity and intensity of itching was done using the validated Arabic version of 5D- itching scale (α= 0.847, p=0.001, Kaiser- Meyer-Oklin value= 0.810). Safety and tolerability of pregabalin was done by using Naranjo’s algorithm. The effect of the pregabalin over the time was assessed using the generalized linear model. Furthermore, to pinpoint the differences in the effect of pregabalin at different time intervals, generalized estimated equations were used. Finally for the assessment of the association among demographics and UP severity, Monte Carlo simulations were preferred. 2015-05 Thesis http://eprints.usm.my/32084/ http://eprints.usm.my/32084/1/Tahir_Mehmood_Khan.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Khan, Tahir Mehmood Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
description	Satu kajian membujur kuasi eksperimen bukan rawak telah dijalankan untuk menilai keberkesanan serta keselamatan dan ketoleranan pengambilan 75mg pregabalin pos hemodialisis (pHD) sekali sehari secara lisan, bagi uremic pruritus (UP) yang resistan pada rawatan, di kalangan pesakit ESRD dalam pusat buah pinggang Aljaber, Hospital King Fahad, Alahsa Arab Saudi. Pengukuran untuk keterukan dan intensiti gatal dilakukan dengan menggunakan skala gatal-5D versi Bahasa Arab yang telah divalidasi (α = 0.847 p = 0.001, Kaiser- Meyer-Oklin value = 0.810). Pengukuran tahap selamat dan ketoleranan pada pregabalin telah dilakukan dengan menggunakan algoritma Naranjo. Model linear teritlak digunakan untuk mengukur kesan selang waktu pengambilan pregabalin. Selanjutnya, untuk menentukan perbezaan kesan pregabalin pada selang masa yang berbeza, persamaan anggaran teritlak digunakan. Akhirnya untuk pentaksiran hubungan unsur-unsur demografi dan tahap keterukan UP, simulasi Monte Carlo telah dipilih. A quasi, non-randomized longitudinal study was conducted to assess the effectiveness of 75mg pregabalin post hemodialysis (pHD) once daily orally in treatment-resistant uremic pruritus (UP), and the safety and tolerability among ESRD patients at Aljaber kidney center, King Fahad Hospital, Alahsa Saudi Arabia. Assessment for the severity and intensity of itching was done using the validated Arabic version of 5D- itching scale (α= 0.847, p=0.001, Kaiser- Meyer-Oklin value= 0.810). Safety and tolerability of pregabalin was done by using Naranjo’s algorithm. The effect of the pregabalin over the time was assessed using the generalized linear model. Furthermore, to pinpoint the differences in the effect of pregabalin at different time intervals, generalized estimated equations were used. Finally for the assessment of the association among demographics and UP severity, Monte Carlo simulations were preferred.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Khan, Tahir Mehmood
author_facet	Khan, Tahir Mehmood
author_sort	Khan, Tahir Mehmood
title	Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
title_short	Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
title_full	Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
title_fullStr	Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
title_full_unstemmed	Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study
title_sort	effectiveness and tolerability of pregabalin usage among patients in king fahad hospital, saudi arabia: a quasi longitudinal study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2015
url	http://eprints.usm.my/32084/1/Tahir_Mehmood_Khan.pdf
_version_	1747820524281528320

Effectiveness And Tolerability Of Pregabalin Usage Among Patients In King Fahad Hospital, Saudi Arabia: A Quasi Longitudinal Study

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