Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities

Nanopartikel emas AuNPs dari bahan bernombor atom (Z) tinggi, garam bukan organik dan glukosa telah digunakan dalam kajian ini untuk meningkatkan sifat-sifat fizikal dan radiologi genipin dosimeter gel untuk aplikasi klinikal yang berbeza. Keberkesanan bahan tambah ini telah dikaji untuk respon peny...

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Main Author:	Aljarrah, Amer Mahmoud Mohammad
Format:	Thesis
Language:	English
Published:	2015
Subjects:	QC1-999 Physics
Online Access:	http://eprints.usm.my/32268/1/AMER_MAHMOUD_MOHAMMAD_ALJARRAH.pdf
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id	my-usm-ep.32268
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spelling	my-usm-ep.322682019-04-12T05:25:43Z Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities 2015-05 Aljarrah, Amer Mahmoud Mohammad QC1-999 Physics Nanopartikel emas AuNPs dari bahan bernombor atom (Z) tinggi, garam bukan organik dan glukosa telah digunakan dalam kajian ini untuk meningkatkan sifat-sifat fizikal dan radiologi genipin dosimeter gel untuk aplikasi klinikal yang berbeza. Keberkesanan bahan tambah ini telah dikaji untuk respon penyerapan dos yang optimum, ketelusan, takat lebur, ketumpatan, dan kesetaraan air terhadap pengukuran dos secara 3D. Formulasi gel boleh harap yang baharu (GP-Gl-AuNPs) telah diformulasi dan dinilai untuk dosimetri 3D menggunakan penilaian optik dan teknik pengimbasan CT untuk bacaan dos. Penambahan glukosa dengan kepekatan optimum 10% (w/w) didapati telah meningkat kestabilan terma gel genipin dan meningkatkan takat lebur (Tm) sebanyak 6°C. Tambahan pula, glukosa membantu melaraskan ketumpatan jisim gel untuk memperoleh sifat-sifat kesetaraan yang dikehendaki. Setitik Tm dan kekuatan gel diperhatikan apabila garam digunakan sebagai bahan tambah. Dengan peningkatan kepekatan garam, kekuatan gel dan Tm menurun. Gold nanoparticles AuNPs of high-Z materials, inorganic salts and glucose have been used in this study to enhance physical and radiological properties of genipin gel dosimeter for different clinical applications. The effectiveness of these additives were investigated for optimum visible absorption dose response, transparency, melting points, density, and water equivalency for 3D dose measurements. A reliable new gel formulation (GP -Gl-AuNPs) was formulated and evaluated for 3D dosimetry using optical evaluation and CT scanning techniques for dose readout. The addition of glucose with optimum concentration of 10% (w/w) was found to improve the thermal stability of the genipin gel and increase its melting point (Tm) by 6°C. Furthermore, glucose helps to adjust the gel mass density to obtain the desired tissue-equivalent properties. A drop of Tm and the gel strength were observed when salt was used as additives. As the salt concentration increase, gel strength and Tm decreased. 2015-05 Thesis http://eprints.usm.my/32268/ http://eprints.usm.my/32268/1/AMER_MAHMOUD_MOHAMMAD_ALJARRAH.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1-999 Physics
spellingShingle	QC1-999 Physics Aljarrah, Amer Mahmoud Mohammad Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
description	Nanopartikel emas AuNPs dari bahan bernombor atom (Z) tinggi, garam bukan organik dan glukosa telah digunakan dalam kajian ini untuk meningkatkan sifat-sifat fizikal dan radiologi genipin dosimeter gel untuk aplikasi klinikal yang berbeza. Keberkesanan bahan tambah ini telah dikaji untuk respon penyerapan dos yang optimum, ketelusan, takat lebur, ketumpatan, dan kesetaraan air terhadap pengukuran dos secara 3D. Formulasi gel boleh harap yang baharu (GP-Gl-AuNPs) telah diformulasi dan dinilai untuk dosimetri 3D menggunakan penilaian optik dan teknik pengimbasan CT untuk bacaan dos. Penambahan glukosa dengan kepekatan optimum 10% (w/w) didapati telah meningkat kestabilan terma gel genipin dan meningkatkan takat lebur (Tm) sebanyak 6°C. Tambahan pula, glukosa membantu melaraskan ketumpatan jisim gel untuk memperoleh sifat-sifat kesetaraan yang dikehendaki. Setitik Tm dan kekuatan gel diperhatikan apabila garam digunakan sebagai bahan tambah. Dengan peningkatan kepekatan garam, kekuatan gel dan Tm menurun. Gold nanoparticles AuNPs of high-Z materials, inorganic salts and glucose have been used in this study to enhance physical and radiological properties of genipin gel dosimeter for different clinical applications. The effectiveness of these additives were investigated for optimum visible absorption dose response, transparency, melting points, density, and water equivalency for 3D dose measurements. A reliable new gel formulation (GP -Gl-AuNPs) was formulated and evaluated for 3D dosimetry using optical evaluation and CT scanning techniques for dose readout. The addition of glucose with optimum concentration of 10% (w/w) was found to improve the thermal stability of the genipin gel and increase its melting point (Tm) by 6°C. Furthermore, glucose helps to adjust the gel mass density to obtain the desired tissue-equivalent properties. A drop of Tm and the gel strength were observed when salt was used as additives. As the salt concentration increase, gel strength and Tm decreased.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Aljarrah, Amer Mahmoud Mohammad
author_facet	Aljarrah, Amer Mahmoud Mohammad
author_sort	Aljarrah, Amer Mahmoud Mohammad
title	Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
title_short	Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
title_full	Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
title_fullStr	Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
title_full_unstemmed	Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities
title_sort	dosimetric study of genipin gelatin-chemical additives polymer gel using 6 mv and 10 mv therapeutic facilities
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Fizik
publishDate	2015
url	http://eprints.usm.my/32268/1/AMER_MAHMOUD_MOHAMMAD_ALJARRAH.pdf
_version_	1747820556436111360

Dosimetric Study Of Genipin Gelatin-Chemical Additives Polymer Gel Using 6 Mv And 10 Mv Therapeutic Facilities

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