Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action

Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-ok...

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Main Author: Sultan Ayesh, Mohammed Saghir
Format: Thesis
Language:English
Published: 2015
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Online Access:http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf
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spelling my-usm-ep.322892019-04-12T05:25:37Z Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action 2015-10 Sultan Ayesh, Mohammed Saghir RS1-441 Pharmacy and materia medica Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-oksidan dan toksisiti ekstrak metanol dan akueus bahagian yang berlainan daripada A. carambola dengan tumpuan untuk elusidasi mekanisme tindakannya. Daripada semua ekstrak yang diuji, ekstrak metanol bahagian daun A. carambola menunjukkan aktiviti antihiperlipidemik terbaik dalam model tikus hiperlipidemik akut teraruh oleh poloxamer-407 berbanding kawalan hiperlipidemik yang setanding dengan aktiviti atorvastatin. Berikutan pemberian kronik sehingga lima minggu, tiada penurunan signifikan diperhatikan dalam aras parameter lipid bagi tikus normal yang dirawat dengan 1000 mg/kg ekstrak metanol daun. Sebaliknya, perbezaan yang signifikan diperhatikan dalam parameter lipid tikus hiperlipidemik teraruh diet tinggi lemak selepas dirawat dengan 500 dan 1000 mg/kg ekstrak metanol daun berbanding kawalan normal. Averrhoa carambola, commonly known as star fruit is one of the widely used herbs in the Malaysian traditional medicine, with the leaf and fruits being the most utilized parts. This study aims to investigate the antihyperlipidaemic effect, antioxidant activity and toxicity of methanolic and aqueous extracts of different parts of A. carambola with focus on elucidating the underlying mechanism of action. Of the tested extracts, the methanolic extract of A. carambola leaf showed the most potent antihyperlipidaemic activity in poloxamer-407-induced acute hyperlipidaemic rat model compared to the hyperlipidaemic control, which was comparable with that of atorvastatin. Upon chronic administration up to five weeks, no significant decrease was observed in the levels of the lipid parameters of normal rats treated with 1000 mg/kg of methanolic extract of leaf. In contrast, significant changes were observed in lipid parameters of high-fat diet induced hyperlipidemic rats after treated with 500 and 1000 mg/kg leaf methanolic extract as compared with the hyperlipidaemic control. 2015-10 Thesis http://eprints.usm.my/32289/ http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Sultan Ayesh, Mohammed Saghir
Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
description Averrhoa carambola, biasanya dikenali sebagai belimbing merupakan salah satu herba yang digunakan secara meluas dalam perubatan tradisional masyarakat Malaysia, daun dan buahnya merupakan bahagian yang paling banyak digunakan. Kajian ini bertujuan menyiasat kesan antihiperlipidemik, aktiviti anti-oksidan dan toksisiti ekstrak metanol dan akueus bahagian yang berlainan daripada A. carambola dengan tumpuan untuk elusidasi mekanisme tindakannya. Daripada semua ekstrak yang diuji, ekstrak metanol bahagian daun A. carambola menunjukkan aktiviti antihiperlipidemik terbaik dalam model tikus hiperlipidemik akut teraruh oleh poloxamer-407 berbanding kawalan hiperlipidemik yang setanding dengan aktiviti atorvastatin. Berikutan pemberian kronik sehingga lima minggu, tiada penurunan signifikan diperhatikan dalam aras parameter lipid bagi tikus normal yang dirawat dengan 1000 mg/kg ekstrak metanol daun. Sebaliknya, perbezaan yang signifikan diperhatikan dalam parameter lipid tikus hiperlipidemik teraruh diet tinggi lemak selepas dirawat dengan 500 dan 1000 mg/kg ekstrak metanol daun berbanding kawalan normal. Averrhoa carambola, commonly known as star fruit is one of the widely used herbs in the Malaysian traditional medicine, with the leaf and fruits being the most utilized parts. This study aims to investigate the antihyperlipidaemic effect, antioxidant activity and toxicity of methanolic and aqueous extracts of different parts of A. carambola with focus on elucidating the underlying mechanism of action. Of the tested extracts, the methanolic extract of A. carambola leaf showed the most potent antihyperlipidaemic activity in poloxamer-407-induced acute hyperlipidaemic rat model compared to the hyperlipidaemic control, which was comparable with that of atorvastatin. Upon chronic administration up to five weeks, no significant decrease was observed in the levels of the lipid parameters of normal rats treated with 1000 mg/kg of methanolic extract of leaf. In contrast, significant changes were observed in lipid parameters of high-fat diet induced hyperlipidemic rats after treated with 500 and 1000 mg/kg leaf methanolic extract as compared with the hyperlipidaemic control.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Sultan Ayesh, Mohammed Saghir
author_facet Sultan Ayesh, Mohammed Saghir
author_sort Sultan Ayesh, Mohammed Saghir
title Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_short Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_full Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_fullStr Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_full_unstemmed Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
title_sort antihyperlipidaemic and antioxidant activities of extracts of different parts of averrhoa carambola and elucidation of their mechanisms of action
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi (School of Pharmaceutical Sciences)
publishDate 2015
url http://eprints.usm.my/32289/1/SULTAN_AYESH_MOHAMMED_SAGHIR_24%28NN%29.pdf
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