Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis

Toksoplasmosis merupakan jangkitan berleluasa di seluruh dunia yang disebabkan oleh Toxoplasma gondii. Jangkitan akut (primer) di dalam kalangan wanita hamil boleh menyebabkan toksoplasmosis kongenital yang mengakibatkan kecacatan neonatal, kerosakan saraf dan mata fetus, atau kematian janin. Oleh s...

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Main Author:	Teh, Ai Ying
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/32318/1/TEH_AI_YING_24%28NN%29.pdf
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id	my-usm-ep.32318
record_format	uketd_dc
spelling	my-usm-ep.323182019-04-12T05:25:19Z Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis 2016-07 Teh, Ai Ying R735-854 Medical education. Medical schools. Research Toksoplasmosis merupakan jangkitan berleluasa di seluruh dunia yang disebabkan oleh Toxoplasma gondii. Jangkitan akut (primer) di dalam kalangan wanita hamil boleh menyebabkan toksoplasmosis kongenital yang mengakibatkan kecacatan neonatal, kerosakan saraf dan mata fetus, atau kematian janin. Oleh sebab itu, penilaian peringkat toksoplasmosis (kronik atau akut) di dalam kalangan wanita hamil adalah penting untuk pengurusan pesakit yang baik. Ujian serologi kekal sebagai pendekatan yang paling biasa untuk diagnosis makmal dan juga penilaian peringkat jangkitan bagi penyakit Toxoplasma. Pengunaan kaedah IgG aviditi telah dibuktikan berguna dalam perbezaan jangkitan toksoplasmosis akut dan kronik. Aviditi IgG adalah rendah pada awal jangkitan dan meningkat secara beransur-ansur dari masa ke masa. Aviditi IgG yang tinggi mengesahkan jangkitan kronik, manakala aviditi IgG yang rendah menunjukkan kemungkinan jangkitan yang baru. Toxoplasmosis is a worldwide infection caused by Toxoplasma gondii. Acute (primary) infection in pregnant women can lead to congenital toxoplasmosis which causes neonatal malformation, neurological damage, eye lesions or fetal death. Therefore, assessment of the stage (chronic or acute) of toxoplasmosis in pregnant women is crucial for appropriate patient management. Serodiagnosis remains the most common approach for laboratory diagnosis of Toxoplasma infection as well as to assess the stage of the infection. Determination of IgG avidity has been proven to be useful in differentiating acute from chronic Toxoplasma infection. The IgG avidity is low at the beginning of the infection and gradually increases over time. High IgG avidity confirms chronic infection while low IgG avidity indicates a probable recent infection. 2016-07 Thesis http://eprints.usm.my/32318/ http://eprints.usm.my/32318/1/TEH_AI_YING_24%28NN%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Penyelidikan Perubatan Molekul (INFORMM)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Teh, Ai Ying Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
description	Toksoplasmosis merupakan jangkitan berleluasa di seluruh dunia yang disebabkan oleh Toxoplasma gondii. Jangkitan akut (primer) di dalam kalangan wanita hamil boleh menyebabkan toksoplasmosis kongenital yang mengakibatkan kecacatan neonatal, kerosakan saraf dan mata fetus, atau kematian janin. Oleh sebab itu, penilaian peringkat toksoplasmosis (kronik atau akut) di dalam kalangan wanita hamil adalah penting untuk pengurusan pesakit yang baik. Ujian serologi kekal sebagai pendekatan yang paling biasa untuk diagnosis makmal dan juga penilaian peringkat jangkitan bagi penyakit Toxoplasma. Pengunaan kaedah IgG aviditi telah dibuktikan berguna dalam perbezaan jangkitan toksoplasmosis akut dan kronik. Aviditi IgG adalah rendah pada awal jangkitan dan meningkat secara beransur-ansur dari masa ke masa. Aviditi IgG yang tinggi mengesahkan jangkitan kronik, manakala aviditi IgG yang rendah menunjukkan kemungkinan jangkitan yang baru. Toxoplasmosis is a worldwide infection caused by Toxoplasma gondii. Acute (primary) infection in pregnant women can lead to congenital toxoplasmosis which causes neonatal malformation, neurological damage, eye lesions or fetal death. Therefore, assessment of the stage (chronic or acute) of toxoplasmosis in pregnant women is crucial for appropriate patient management. Serodiagnosis remains the most common approach for laboratory diagnosis of Toxoplasma infection as well as to assess the stage of the infection. Determination of IgG avidity has been proven to be useful in differentiating acute from chronic Toxoplasma infection. The IgG avidity is low at the beginning of the infection and gradually increases over time. High IgG avidity confirms chronic infection while low IgG avidity indicates a probable recent infection.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Teh, Ai Ying
author_facet	Teh, Ai Ying
author_sort	Teh, Ai Ying
title	Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
title_short	Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
title_full	Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
title_fullStr	Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
title_full_unstemmed	Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
title_sort	identification of potential toxoplasma gondii cdna phage clones and production of the corresponding recombinant proteins in the development of igg avidity assay for serodiagnosis of toxoplasmosis
granting_institution	Universiti Sains Malaysia
granting_department	Institut Penyelidikan Perubatan Molekul (INFORMM)
publishDate	2016
url	http://eprints.usm.my/32318/1/TEH_AI_YING_24%28NN%29.pdf
_version_	1747820565259878400

Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis

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