Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)

Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)

Keloid adalah penyakit kulit fibroproliferatif yang terbentuk disebabkan oleh tindak balas luka yang tidak normal pada individu tertentu. Perubahan terhadap faktor pertumbuhan dan sitokin dalam proses penyembuhan yang tidak normal membentuk keadaan yang tidak seimbang antara sintesis dan degradasi k...

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Main Author: Kamarulzaman, Siti Arffah
Format: Thesis
Language:English
Published: 2013
Subjects:
R5-130.5 General works
Online Access:http://eprints.usm.my/36420/1/Dr._Siti_Arefah_Kamarulzaman_TSTZ_%28NN24%29.pdf
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spelling my-usm-ep.364202019-04-12T05:26:11Z Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF) 2013-07 Kamarulzaman, Siti Arffah R5-130.5 General works Keloid adalah penyakit kulit fibroproliferatif yang terbentuk disebabkan oleh tindak balas luka yang tidak normal pada individu tertentu. Perubahan terhadap faktor pertumbuhan dan sitokin dalam proses penyembuhan yang tidak normal membentuk keadaan yang tidak seimbang antara sintesis dan degradasi kolagen dan komponen ekstraselular matriks yang lain. Pelbagai rawatan telah dicuba untuk keloid, tetapi secara klinikal, kebanyakan terapi masih tidak memuaskan. Kepentingan saintifik tokotrienol telah meningkat kerana sifatnya sebagai antioksida dan sifat berkaitan pelindung. Walau bagaimanapun, terdapat kekurangan bukti saintifik mengenai keberkesanan tokotrienol dalam pengurusan keloid dan parut. Oleh itu, kajian ini telah dijalankan untuk menyiasat kesan-kesan berfaedah pecahan tokotrienol (TRF) minyak kelapa sawit pada fibroblas keloid. Keloids are dermal fibroproliferative disease that developed due to abnormal wound response in predisposed individuals. The alteration of growth factors and cytokines in abnormal healing process formed an imbalanced condition between collagen and other extracellular matrix components synthesis and degradation. Various treatments for keloids have been tried but most of the therapeutic approaches remain clinically unsatisfactory. Tocotrienols have gained increasing scientific interest due to their antioxidant and related protective properties. However, there is lack of scientific evidence regarding the efficacy and therapies of tocotrienol in keloid and scar management. Thus, this study was carried out to investigate the effects of palm oil tocotrienol rich fraction (TRF) on human keloid fibroblasts. Keloids and normal skin were collected as samples in this study. 2013-07 Thesis http://eprints.usm.my/36420/ http://eprints.usm.my/36420/1/Dr._Siti_Arefah_Kamarulzaman_TSTZ_%28NN24%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan (School of Medical Sciences)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R5-130.5 General works
spellingShingle R5-130.5 General works
Kamarulzaman, Siti Arffah
Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
description Keloid adalah penyakit kulit fibroproliferatif yang terbentuk disebabkan oleh tindak balas luka yang tidak normal pada individu tertentu. Perubahan terhadap faktor pertumbuhan dan sitokin dalam proses penyembuhan yang tidak normal membentuk keadaan yang tidak seimbang antara sintesis dan degradasi kolagen dan komponen ekstraselular matriks yang lain. Pelbagai rawatan telah dicuba untuk keloid, tetapi secara klinikal, kebanyakan terapi masih tidak memuaskan. Kepentingan saintifik tokotrienol telah meningkat kerana sifatnya sebagai antioksida dan sifat berkaitan pelindung. Walau bagaimanapun, terdapat kekurangan bukti saintifik mengenai keberkesanan tokotrienol dalam pengurusan keloid dan parut. Oleh itu, kajian ini telah dijalankan untuk menyiasat kesan-kesan berfaedah pecahan tokotrienol (TRF) minyak kelapa sawit pada fibroblas keloid. Keloids are dermal fibroproliferative disease that developed due to abnormal wound response in predisposed individuals. The alteration of growth factors and cytokines in abnormal healing process formed an imbalanced condition between collagen and other extracellular matrix components synthesis and degradation. Various treatments for keloids have been tried but most of the therapeutic approaches remain clinically unsatisfactory. Tocotrienols have gained increasing scientific interest due to their antioxidant and related protective properties. However, there is lack of scientific evidence regarding the efficacy and therapies of tocotrienol in keloid and scar management. Thus, this study was carried out to investigate the effects of palm oil tocotrienol rich fraction (TRF) on human keloid fibroblasts. Keloids and normal skin were collected as samples in this study.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Kamarulzaman, Siti Arffah
author_facet Kamarulzaman, Siti Arffah
author_sort Kamarulzaman, Siti Arffah
title Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
title_short Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
title_full Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
title_fullStr Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
title_full_unstemmed Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)
title_sort gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (trf)
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan (School of Medical Sciences)
publishDate 2013
url http://eprints.usm.my/36420/1/Dr._Siti_Arefah_Kamarulzaman_TSTZ_%28NN24%29.pdf
_version_ 1747820636310339584

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