Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats

Kajian bertujuan untuk mengetahui kesan stres haba akut pada ekspresi protein HSP70, c-Fos and DREAM dalam usaha memahami mekanisma stres di peringkat neonat dan kesan pada kehidupan berikutnya. Fasa pertama kajian menilai ujian berenang secara paksa (FST) sebagai model induksi stres sederhana pada...

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Main Author:	Mat Taib, Che Norma
Format:	Thesis
Language:	English
Published:	2014
Subjects:	R5-130.5 General works
Online Access:	http://eprints.usm.my/36428/1/Dr._Che_Norma_Binti_Mat_Taib_TSTZ_%28NN24%29.pdf
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spelling	my-usm-ep.364282019-04-12T05:26:04Z Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats 2014 Mat Taib, Che Norma R5-130.5 General works Kajian bertujuan untuk mengetahui kesan stres haba akut pada ekspresi protein HSP70, c-Fos and DREAM dalam usaha memahami mekanisma stres di peringkat neonat dan kesan pada kehidupan berikutnya. Fasa pertama kajian menilai ujian berenang secara paksa (FST) sebagai model induksi stres sederhana pada tikus neonat. FST dilakukan pada umur 7, 8 dan 9 hari selepas kelahiran. Kesemua tikus neonat hidup dan berada dalam keadaan sihat selepas FST. Berat badan mereka menurun pada hari ke 14 hingga 42 dan meningkat semula dan menyamai kumpulan kawalan pada hari ke 49 dan seterusnya. Nisbah sel neutrofil dan limfosit meningkat secara signifikan pada kumpulan FST berbanding dengan kumpulan kawalan. Skor BrdU menurun pada kumpulan FST berbanding tikus kawalan membuktikan berlakunya neurogenesis. This current study was to explore the effect of acute thermal stress on the expression of HSP70, c-Fos and DREAM proteins in an attempt to understand the mechanisms of neonatal stress and the effect on stress later in life. Phase one of this study evaluated forced swimming test (FST) as a model for induction of moderate stress in neonatal rats. Forced swimming test was applied to neonatal rats on days 7, 8 and 9 of life. All the pups survived and remained healthy after FST. From day 14 to day 42, the FST group had significantly lower body weights when compared to the control group. Their body weights were back to control levels on day 49 onwards. Forced swimming test significantly increased neutrophil/lymphocyte ratios in the stress group compared to controls. 2014 Thesis http://eprints.usm.my/36428/ http://eprints.usm.my/36428/1/Dr._Che_Norma_Binti_Mat_Taib_TSTZ_%28NN24%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan (School of Medical Sciences)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-130.5 General works
spellingShingle	R5-130.5 General works Mat Taib, Che Norma Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
description	Kajian bertujuan untuk mengetahui kesan stres haba akut pada ekspresi protein HSP70, c-Fos and DREAM dalam usaha memahami mekanisma stres di peringkat neonat dan kesan pada kehidupan berikutnya. Fasa pertama kajian menilai ujian berenang secara paksa (FST) sebagai model induksi stres sederhana pada tikus neonat. FST dilakukan pada umur 7, 8 dan 9 hari selepas kelahiran. Kesemua tikus neonat hidup dan berada dalam keadaan sihat selepas FST. Berat badan mereka menurun pada hari ke 14 hingga 42 dan meningkat semula dan menyamai kumpulan kawalan pada hari ke 49 dan seterusnya. Nisbah sel neutrofil dan limfosit meningkat secara signifikan pada kumpulan FST berbanding dengan kumpulan kawalan. Skor BrdU menurun pada kumpulan FST berbanding tikus kawalan membuktikan berlakunya neurogenesis. This current study was to explore the effect of acute thermal stress on the expression of HSP70, c-Fos and DREAM proteins in an attempt to understand the mechanisms of neonatal stress and the effect on stress later in life. Phase one of this study evaluated forced swimming test (FST) as a model for induction of moderate stress in neonatal rats. Forced swimming test was applied to neonatal rats on days 7, 8 and 9 of life. All the pups survived and remained healthy after FST. From day 14 to day 42, the FST group had significantly lower body weights when compared to the control group. Their body weights were back to control levels on day 49 onwards. Forced swimming test significantly increased neutrophil/lymphocyte ratios in the stress group compared to controls.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mat Taib, Che Norma
author_facet	Mat Taib, Che Norma
author_sort	Mat Taib, Che Norma
title	Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
title_short	Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
title_full	Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
title_fullStr	Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
title_full_unstemmed	Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
title_sort	structural changes of hippocampi and expression of hsp70, c-fos and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan (School of Medical Sciences)
publishDate	2014
url	http://eprints.usm.my/36428/1/Dr._Che_Norma_Binti_Mat_Taib_TSTZ_%28NN24%29.pdf
_version_	1747820638021615616

Structural changes of hippocampi and expression of HSP70, C-FOS and dream proteins in the spinal cord after acute thermal stimulus or early stress-experienced rats

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