The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model

Natural CD4+CD25+Foxp3+ T regulatory cell (nTreg) is a subset of regulatory T cell that is derived from the thymus. The immunodownregulatory function of nTreg cells is critical in mediating peripheral self-tolerance. Concordantly, the antiinflammatory properties of peroxisome proliferator-activated...

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Main Author:	Zulkafli, Nor Effa Syazuli
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RC648-665 Diseases of the endocrine glands Clinical endocrinology
Online Access:	http://eprints.usm.my/37739/1/Dr._Nor_Effa_Syazuli_Zulkafli_24ms.pdf
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id	my-usm-ep.37739
record_format	uketd_dc
spelling	my-usm-ep.377392019-04-12T05:25:34Z The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model 2015-11 Zulkafli, Nor Effa Syazuli RC648-665 Diseases of the endocrine glands. Clinical endocrinology Natural CD4+CD25+Foxp3+ T regulatory cell (nTreg) is a subset of regulatory T cell that is derived from the thymus. The immunodownregulatory function of nTreg cells is critical in mediating peripheral self-tolerance. Concordantly, the antiinflammatory properties of peroxisome proliferator-activated receptor (PPAR have been intensely studied in recent years. Given their crucial role in immune regulation, the current study was conducted to decipher the modulatory mechanism by PPAR ligands in nTreg cells of BALB/c, and the Type 1 Diabetic (T1D) model, Non Obese Diabetic (NOD) as well as in the Non Obese Resistant (NOR) mice. Initially, we optimized the time-points and the concentrations of IL-2 for in vitro culture of nTreg cells in BALB/c mice. Subsequently, the functional analysis of isolated nTreg cells of BALB/c mice was measured. 2015-11 Thesis http://eprints.usm.my/37739/ http://eprints.usm.my/37739/1/Dr._Nor_Effa_Syazuli_Zulkafli_24ms.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC648-665 Diseases of the endocrine glands Clinical endocrinology
spellingShingle	RC648-665 Diseases of the endocrine glands Clinical endocrinology Zulkafli, Nor Effa Syazuli The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
description	Natural CD4+CD25+Foxp3+ T regulatory cell (nTreg) is a subset of regulatory T cell that is derived from the thymus. The immunodownregulatory function of nTreg cells is critical in mediating peripheral self-tolerance. Concordantly, the antiinflammatory properties of peroxisome proliferator-activated receptor (PPAR have been intensely studied in recent years. Given their crucial role in immune regulation, the current study was conducted to decipher the modulatory mechanism by PPAR ligands in nTreg cells of BALB/c, and the Type 1 Diabetic (T1D) model, Non Obese Diabetic (NOD) as well as in the Non Obese Resistant (NOR) mice. Initially, we optimized the time-points and the concentrations of IL-2 for in vitro culture of nTreg cells in BALB/c mice. Subsequently, the functional analysis of isolated nTreg cells of BALB/c mice was measured.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Zulkafli, Nor Effa Syazuli
author_facet	Zulkafli, Nor Effa Syazuli
author_sort	Zulkafli, Nor Effa Syazuli
title	The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
title_short	The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
title_full	The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
title_fullStr	The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
title_full_unstemmed	The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
title_sort	influence of ppary ligands on the expression of foxp3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2015
url	http://eprints.usm.my/37739/1/Dr._Nor_Effa_Syazuli_Zulkafli_24ms.pdf
_version_	1747820671451267072

The influence of ppary ligands on the expression of FOXP3 in natural t-regulatory cells in balb/c and type 1 diabetes mouse model

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