A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia

Introduction: Magnesium sulphate has been shown to be the optimal anticonvulsant in preventing the recurrence of seizures in eclampsia and in seizure prophylaxis in preeclampsia. Traditionally, seizure prophylaxis has been administered before delivery and continued postpartum for an arbitrary time,...

Full description

Saved in:

Bibliographic Details
Main Author:	Yunus, Affendi
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/37752/1/Pages_from_Affendi_Yunus.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.37752
record_format	uketd_dc
spelling	my-usm-ep.377522019-04-12T05:26:46Z A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia 2010-11 Yunus, Affendi RG Gynecology and obstetrics Introduction: Magnesium sulphate has been shown to be the optimal anticonvulsant in preventing the recurrence of seizures in eclampsia and in seizure prophylaxis in preeclampsia. Traditionally, seizure prophylaxis has been administered before delivery and continued postpartum for an arbitrary time, usually 24 hours. Objectives: The primary objectives of this study were to evaluate the safety and effectiveness of using clinical parameters to signal cessation of postpartum magnesium sulphate therapy among patients with Severe Preeclampsia. Methodology: A randomized trial of postpartum magnesium sulphate therapy was conducted in HRPZII, Kota Bharu and HUSM, Kubang Kerian from December 2009 to September 2010. The control group received 24 hours of therapy, and the intervention group received therapy until fulfilled clinical criteria for discontinuation of seizure prophylaxis. The Independent t test, Chi-square test, and Fisher’s exact test were used for analysis of data. A probability value of <0.05 was considered statistically significant. Results: There were 52 patients in the control group and 50 patients in the intervention group. The intervention group had a significantly shorter duration of therapy (p< 0.05). There were no differences in mean booking BMI, weight on admission, systolic blood pressure and platelet level between two groups. However there were significance differences in mean age of the patients, delivery gestational age, diastolic blood pressure and uric acid level between two groups. There was no patient in this study had eclampsia or required the reinitiation of therapy. Conclusions: Clinical parameters can be used effectively and safe to shorten the duration of postpartum magnesium sulphate therapy in patients with severe preeclampsia. 2010-11 Thesis http://eprints.usm.my/37752/ http://eprints.usm.my/37752/1/Pages_from_Affendi_Yunus.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Yunus, Affendi A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
description	Introduction: Magnesium sulphate has been shown to be the optimal anticonvulsant in preventing the recurrence of seizures in eclampsia and in seizure prophylaxis in preeclampsia. Traditionally, seizure prophylaxis has been administered before delivery and continued postpartum for an arbitrary time, usually 24 hours. Objectives: The primary objectives of this study were to evaluate the safety and effectiveness of using clinical parameters to signal cessation of postpartum magnesium sulphate therapy among patients with Severe Preeclampsia. Methodology: A randomized trial of postpartum magnesium sulphate therapy was conducted in HRPZII, Kota Bharu and HUSM, Kubang Kerian from December 2009 to September 2010. The control group received 24 hours of therapy, and the intervention group received therapy until fulfilled clinical criteria for discontinuation of seizure prophylaxis. The Independent t test, Chi-square test, and Fisher’s exact test were used for analysis of data. A probability value of <0.05 was considered statistically significant. Results: There were 52 patients in the control group and 50 patients in the intervention group. The intervention group had a significantly shorter duration of therapy (p< 0.05). There were no differences in mean booking BMI, weight on admission, systolic blood pressure and platelet level between two groups. However there were significance differences in mean age of the patients, delivery gestational age, diastolic blood pressure and uric acid level between two groups. There was no patient in this study had eclampsia or required the reinitiation of therapy. Conclusions: Clinical parameters can be used effectively and safe to shorten the duration of postpartum magnesium sulphate therapy in patients with severe preeclampsia.
format	Thesis
qualification_level	Master's degree
author	Yunus, Affendi
author_facet	Yunus, Affendi
author_sort	Yunus, Affendi
title	A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
title_short	A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
title_full	A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
title_fullStr	A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
title_full_unstemmed	A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
title_sort	randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2010
url	http://eprints.usm.my/37752/1/Pages_from_Affendi_Yunus.pdf
_version_	1747820672426442752

A randomised controlled trial of mgso4 therapy for 24 hours versus early cessation in patients with severe preeclampsia

Similar Items