Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma

Introduction: For tumor development and progression, angiogenesis and apoptosis play a crucial role. No study so far has tried to associate these two activities in tumor cells as well as correlation of both activities in the tumor and the endothelial cells. Conclusion: This study supports the role o...

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Main Author:	Yusuf, Yusri
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RB37-56.5 Clinical pathology Laboratory technique
Online Access:	http://eprints.usm.my/37793/1/Pages_from_Yusri_Yusuf.pdf
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id	my-usm-ep.37793
record_format	uketd_dc
spelling	my-usm-ep.377932019-04-12T05:26:59Z Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma 2010 Yusuf, Yusri RB37-56.5 Clinical pathology. Laboratory technique Introduction: For tumor development and progression, angiogenesis and apoptosis play a crucial role. No study so far has tried to associate these two activities in tumor cells as well as correlation of both activities in the tumor and the endothelial cells. Conclusion: This study supports the role of endothelial cells in survival and regression of tumor cells in tumoregenesis. Thus, the inhibition of endothelial cells survival factor or activation ofendothelial cells death is a promising prospect as a candidate for tumor therapy. All the proteins used in this study might be potential as a useful marker for diagnosis of specific histologic subtypes especially Bcl-2 since there is diversity in expression amongst the various histologic subtypes in STS. An increase in angiogenic activity may inhibit apoptotic tumor cells death which leads to cell proliferation. However, the angiogenic activity was independent of anti-‐apoptotic activities. A better understanding of their relations probably provides the basis for more rational cancer therapies in the future. 2010 Thesis http://eprints.usm.my/37793/ http://eprints.usm.my/37793/1/Pages_from_Yusri_Yusuf.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RB37-56.5 Clinical pathology Laboratory technique
spellingShingle	RB37-56.5 Clinical pathology Laboratory technique Yusuf, Yusri Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
description	Introduction: For tumor development and progression, angiogenesis and apoptosis play a crucial role. No study so far has tried to associate these two activities in tumor cells as well as correlation of both activities in the tumor and the endothelial cells. Conclusion: This study supports the role of endothelial cells in survival and regression of tumor cells in tumoregenesis. Thus, the inhibition of endothelial cells survival factor or activation ofendothelial cells death is a promising prospect as a candidate for tumor therapy. All the proteins used in this study might be potential as a useful marker for diagnosis of specific histologic subtypes especially Bcl-2 since there is diversity in expression amongst the various histologic subtypes in STS. An increase in angiogenic activity may inhibit apoptotic tumor cells death which leads to cell proliferation. However, the angiogenic activity was independent of anti-‐apoptotic activities. A better understanding of their relations probably provides the basis for more rational cancer therapies in the future.
format	Thesis
qualification_level	Master's degree
author	Yusuf, Yusri
author_facet	Yusuf, Yusri
author_sort	Yusuf, Yusri
title	Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
title_short	Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
title_full	Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
title_fullStr	Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
title_full_unstemmed	Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
title_sort	expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2010
url	http://eprints.usm.my/37793/1/Pages_from_Yusri_Yusuf.pdf
_version_	1747820674373648384

Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma

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