A clinicopathologic study on triple-negative breast cancer patients: HUSM experience

Breast cancer is the most common cancer among Malaysian women. There are many prognostic factors contributing to the disease and the outcome of the patients. Triple negative breast cancers are defined by a lack of expression of oestrogen, progesterone, and c erbB-2 receptors. They tend to have a hig...

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Main Author:	Saidin, Usman Sani
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/38162/1/Pages_from_Usman_Sani_Saidin-RG_GYNECOLOGY.pdf
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id	my-usm-ep.38162
record_format	uketd_dc
spelling	my-usm-ep.381622019-04-12T05:26:44Z A clinicopathologic study on triple-negative breast cancer patients: HUSM experience 2011 Saidin, Usman Sani RG Gynecology and obstetrics Breast cancer is the most common cancer among Malaysian women. There are many prognostic factors contributing to the disease and the outcome of the patients. Triple negative breast cancers are defined by a lack of expression of oestrogen, progesterone, and c erbB-2 receptors. They tend to have a higher grade with a poorer outcome compared to non-triple negative breast cancers. Hence, a retrospective study was carried out aiming to observe the association of triple negative (oestrogen receptor (ER), progesterone receptor (PR) and c erbB-2) breast cancer patients to the pathological (histological subtype, tumour grade, tumour size and lymph node involvement) and non pathological parameters (patient’s age and ethnicity). Twenty three cases of triple negative breast cancer among 115 cases of breast cancer diagnosed in three years (2002 to 2004) were reviewed. They represented 20.0% of total breast cancer patients. There were significant association between triple negative breast cancer with tumour size, lymph node involvement and lymphovascular invasion. However, age, race, histological subtype and histological grade did not show significant association. From these findings, we conclude that tumour size is the strongest factor associated with the triple negative breast cancer. Besides that, lymph node involvement is also associated with triple negative breast cancer. However, lymph vascular invasion is not associated with triple negative vascular breast cancer. 2011 Thesis http://eprints.usm.my/38162/ http://eprints.usm.my/38162/1/Pages_from_Usman_Sani_Saidin-RG_GYNECOLOGY.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Saidin, Usman Sani A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
description	Breast cancer is the most common cancer among Malaysian women. There are many prognostic factors contributing to the disease and the outcome of the patients. Triple negative breast cancers are defined by a lack of expression of oestrogen, progesterone, and c erbB-2 receptors. They tend to have a higher grade with a poorer outcome compared to non-triple negative breast cancers. Hence, a retrospective study was carried out aiming to observe the association of triple negative (oestrogen receptor (ER), progesterone receptor (PR) and c erbB-2) breast cancer patients to the pathological (histological subtype, tumour grade, tumour size and lymph node involvement) and non pathological parameters (patient’s age and ethnicity). Twenty three cases of triple negative breast cancer among 115 cases of breast cancer diagnosed in three years (2002 to 2004) were reviewed. They represented 20.0% of total breast cancer patients. There were significant association between triple negative breast cancer with tumour size, lymph node involvement and lymphovascular invasion. However, age, race, histological subtype and histological grade did not show significant association. From these findings, we conclude that tumour size is the strongest factor associated with the triple negative breast cancer. Besides that, lymph node involvement is also associated with triple negative breast cancer. However, lymph vascular invasion is not associated with triple negative vascular breast cancer.
format	Thesis
qualification_level	Master's degree
author	Saidin, Usman Sani
author_facet	Saidin, Usman Sani
author_sort	Saidin, Usman Sani
title	A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
title_short	A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
title_full	A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
title_fullStr	A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
title_full_unstemmed	A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
title_sort	clinicopathologic study on triple-negative breast cancer patients: husm experience
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2011
url	http://eprints.usm.my/38162/1/Pages_from_Usman_Sani_Saidin-RG_GYNECOLOGY.pdf
_version_	1747820686859042816

A clinicopathologic study on triple-negative breast cancer patients: HUSM experience

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