Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix

Introduction: Cervical cancer is a preventable and the third most common cancer to occur in the reproductive age women. It is caused by the Human Papilloma Viruses. The ADAM 9 protein is involved in basement membrane degradation and tumor metastasis in certain types of tumor. Objective: Objectives...

Full description

Saved in:

Bibliographic Details
Main Author:	Mohd Isa, Seoparjoo Azmel
Format:	Thesis
Language:	English
Published:	2012
Subjects:	RC254-282 Neoplasms Tumors Oncology (including Cancer)
Online Access:	http://eprints.usm.my/39233/1/Dr._Seoparjoo_Azmel_Mohd_Isa-24_pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.39233
record_format	uketd_dc
spelling	my-usm-ep.392332019-04-12T05:26:25Z Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix 2012 Mohd Isa, Seoparjoo Azmel RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Introduction: Cervical cancer is a preventable and the third most common cancer to occur in the reproductive age women. It is caused by the Human Papilloma Viruses. The ADAM 9 protein is involved in basement membrane degradation and tumor metastasis in certain types of tumor. Objective: Objectives of this study are to describe the characteristics of cervical cancer and factors associated with ADAM 9 expression in cervical cancer. Methodology: Retrospective record review was done in February 2012 using patients’ case notes obtained from the Medical Record Unit, Universiti Sains Malaysia Hospital. Data was entered and analyze using SPSS version 19. Result: There were 95 cases of cervical cancer included in this study. Majority were Malays 76 (80.0%), non smoker 85 (89.5%), without co-morbid disease (86.4%), had no distant metastasis 54 (56.8%) and absent of lymph nodes involvement 71 (74.7%). Squamous cell carcinoma was the most common type of cervical cancer 67 (70.5%). Mean age of subjects were 53.89 (10.83). The statistically significant associated factors for ADAM9 positive staining among cervical cancer were tumor size (p=0.004), distant metastasis (p=0.009) and histological type of cervical cancer, which is squamous cell carcinoma (p=0.017). Women with squamous cell carcinoma of cervical cancer has 7.39 times odds of having ADAM9 staining positive as compared with women with adenocarcinoma of cervical cancer (95% CI 1.42, 38.51; p=0.017). Cervical cancer patients who had distant metastasis has 12.82 times chances of having ADAM9 staining positive as compared with cervical cancer patients without distant metastasis (95% CI 1.91, 86.13; p=0.009). while with every 1mm increment in tumor size, women with cervical cancer will had 1.08 odds times od having ADAM9 staining positive (95% CI 1.02, 1.13; p=0.004). Conclusion: In this study we identified that ADAM 9 expression associated with large size of the tumor, lymph nodes involvement, distant metastasis and also type of carcinoma. This concludes that aggressive tumor expressed ADAM 9 2012 Thesis http://eprints.usm.my/39233/ http://eprints.usm.my/39233/1/Dr._Seoparjoo_Azmel_Mohd_Isa-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC254-282 Neoplasms Tumors Oncology (including Cancer)
spellingShingle	RC254-282 Neoplasms Tumors Oncology (including Cancer) Mohd Isa, Seoparjoo Azmel Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
description	Introduction: Cervical cancer is a preventable and the third most common cancer to occur in the reproductive age women. It is caused by the Human Papilloma Viruses. The ADAM 9 protein is involved in basement membrane degradation and tumor metastasis in certain types of tumor. Objective: Objectives of this study are to describe the characteristics of cervical cancer and factors associated with ADAM 9 expression in cervical cancer. Methodology: Retrospective record review was done in February 2012 using patients’ case notes obtained from the Medical Record Unit, Universiti Sains Malaysia Hospital. Data was entered and analyze using SPSS version 19. Result: There were 95 cases of cervical cancer included in this study. Majority were Malays 76 (80.0%), non smoker 85 (89.5%), without co-morbid disease (86.4%), had no distant metastasis 54 (56.8%) and absent of lymph nodes involvement 71 (74.7%). Squamous cell carcinoma was the most common type of cervical cancer 67 (70.5%). Mean age of subjects were 53.89 (10.83). The statistically significant associated factors for ADAM9 positive staining among cervical cancer were tumor size (p=0.004), distant metastasis (p=0.009) and histological type of cervical cancer, which is squamous cell carcinoma (p=0.017). Women with squamous cell carcinoma of cervical cancer has 7.39 times odds of having ADAM9 staining positive as compared with women with adenocarcinoma of cervical cancer (95% CI 1.42, 38.51; p=0.017). Cervical cancer patients who had distant metastasis has 12.82 times chances of having ADAM9 staining positive as compared with cervical cancer patients without distant metastasis (95% CI 1.91, 86.13; p=0.009). while with every 1mm increment in tumor size, women with cervical cancer will had 1.08 odds times od having ADAM9 staining positive (95% CI 1.02, 1.13; p=0.004). Conclusion: In this study we identified that ADAM 9 expression associated with large size of the tumor, lymph nodes involvement, distant metastasis and also type of carcinoma. This concludes that aggressive tumor expressed ADAM 9
format	Thesis
qualification_level	Master's degree
author	Mohd Isa, Seoparjoo Azmel
author_facet	Mohd Isa, Seoparjoo Azmel
author_sort	Mohd Isa, Seoparjoo Azmel
title	Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
title_short	Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
title_full	Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
title_fullStr	Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
title_full_unstemmed	Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
title_sort	adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2012
url	http://eprints.usm.my/39233/1/Dr._Seoparjoo_Azmel_Mohd_Isa-24_pages.pdf
_version_	1747820735651381248

Adam-9 expression in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix

Similar Items