Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia

The use of advanced technology in the field of genetic had influenced and upgraded the dicipline and had leds to a lot of advances in the genetics of human populations. Among them, microarray of single nucleotide polymorphism (SNP) allows large coverage of the human genome. SNP microarray was use...

Full description

Saved in:

Bibliographic Details
Main Author:	Ab Rajab, Nur Shafawati
Format:	Thesis
Language:	English
Published:	2013
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/39283/1/Dr._Shafawati_Ab._Rajab-24_pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.39283
record_format	uketd_dc
spelling	my-usm-ep.392832019-04-12T05:26:11Z Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia 2013-07 Ab Rajab, Nur Shafawati R5-920 Medicine (General) The use of advanced technology in the field of genetic had influenced and upgraded the dicipline and had leds to a lot of advances in the genetics of human populations. Among them, microarray of single nucleotide polymorphism (SNP) allows large coverage of the human genome. SNP microarray was used for this study to find and characterize genetic differences among Malays sub-ethnic groups in Peninsular Malaysia. The Malay sub-ethnic groups of Peninsular Malaysia consist of several sub-groups that differ in a variety of factors including language, history of migration to Malaysia, origins, customs and daily social life. One hundred and thirty five Malays participated in this study and consisted of Kelantan Malay, Minang Malay, Javanese Malay, Bugis Malay, Kedah Malay Champa Malay, Pattani Malay and Banjar Malay. From our study, more than 50,000 SNPs were successfully genotyped. The study found that there is indeed allele frequency differences among the Malay subethnic groups which absolutely show their differences. In addition, this study goes deep into Malay differences by analyzing their differences of Linkage disequilibrium (LD), haplotype and tag SNPs on three selected chromosomes that showed the highest genetic distances. More on, SNP identification for each sub-ethnic group can be produced using tag SNPs. This study further investigated the related genes which were identified. There were 31 SNPs involved in the discovery of a strong LD block which could identity each of sub-ethnic Malay based on selected tag SNPs. The end result of this study is the discovery of the SNP identity for each sub-ethnic Malay group apart from Champa Malays whichdid not have a strong LD block to be interpreted. In addition, there were six genes of interest that could be attributed to Malay sub-ethnic groups, namely FRYL,SGCB, LIG1, LSM14A, LARGE and FAM118A genes. However, further investigations need to be done to confirm these findings. 2013-07 Thesis http://eprints.usm.my/39283/ http://eprints.usm.my/39283/1/Dr._Shafawati_Ab._Rajab-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Ab Rajab, Nur Shafawati Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
description	The use of advanced technology in the field of genetic had influenced and upgraded the dicipline and had leds to a lot of advances in the genetics of human populations. Among them, microarray of single nucleotide polymorphism (SNP) allows large coverage of the human genome. SNP microarray was used for this study to find and characterize genetic differences among Malays sub-ethnic groups in Peninsular Malaysia. The Malay sub-ethnic groups of Peninsular Malaysia consist of several sub-groups that differ in a variety of factors including language, history of migration to Malaysia, origins, customs and daily social life. One hundred and thirty five Malays participated in this study and consisted of Kelantan Malay, Minang Malay, Javanese Malay, Bugis Malay, Kedah Malay Champa Malay, Pattani Malay and Banjar Malay. From our study, more than 50,000 SNPs were successfully genotyped. The study found that there is indeed allele frequency differences among the Malay subethnic groups which absolutely show their differences. In addition, this study goes deep into Malay differences by analyzing their differences of Linkage disequilibrium (LD), haplotype and tag SNPs on three selected chromosomes that showed the highest genetic distances. More on, SNP identification for each sub-ethnic group can be produced using tag SNPs. This study further investigated the related genes which were identified. There were 31 SNPs involved in the discovery of a strong LD block which could identity each of sub-ethnic Malay based on selected tag SNPs. The end result of this study is the discovery of the SNP identity for each sub-ethnic Malay group apart from Champa Malays whichdid not have a strong LD block to be interpreted. In addition, there were six genes of interest that could be attributed to Malay sub-ethnic groups, namely FRYL,SGCB, LIG1, LSM14A, LARGE and FAM118A genes. However, further investigations need to be done to confirm these findings.
format	Thesis
qualification_level	Master's degree
author	Ab Rajab, Nur Shafawati
author_facet	Ab Rajab, Nur Shafawati
author_sort	Ab Rajab, Nur Shafawati
title	Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
title_short	Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
title_full	Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
title_fullStr	Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
title_full_unstemmed	Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia
title_sort	genome-wide snp microarray analysis among malay sub-ethnic groups in peninsular malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2013
url	http://eprints.usm.my/39283/1/Dr._Shafawati_Ab._Rajab-24_pages.pdf
_version_	1747820738820177920

Genome-wide snp microarray analysis among Malay sub-ethnic groups in peninsular Malaysia

Similar Items