A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia

Background: There have been inconsistent findings in the association between colorectal cancer and smoking exposure. Most reported data were from western population groups with only few involving Asian population while there’re no available local data from Malaysia. As the causes of colorectal ca...

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Main Author:	Euxian, Lee
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RC254-282 Neoplasms Tumors Oncology (including Cancer)
Online Access:	http://eprints.usm.my/39373/1/Dr_Lee_Euxian_%28_General_Surgery%29-24_pages.pdf
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id	my-usm-ep.39373
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spelling	my-usm-ep.393732019-04-12T05:26:04Z A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia 2014 Euxian, Lee RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Background: There have been inconsistent findings in the association between colorectal cancer and smoking exposure. Most reported data were from western population groups with only few involving Asian population while there’re no available local data from Malaysia. As the causes of colorectal cancer are multifactorial, the genetic susceptibility, lifestyle and diet difference between Western and Asian population may be important in determining the overall individual risks across the world. Methods: This study investigates such association in our local population at Hospital Universiti Sains Malaysia in Kelantan. Our case-control study involves patients diagnosed with colorectal cancer from 2005 till 2011 which is matched to a group of controls without the tumour. Data were collected from the patients file records and supplemented further by phone interviews or clinic follow up to complete the validated study proforma. We included a total of 92 cases matched with 92 controls. Results: Current regular smokers have an overall significant association and increased risk of developing CRC (OR = 2.26: CI 95% 0.90-5.89). Increasing number of cigarettes smoked per day is related towards higher rectal cancer risk as compared to colon cancer (p value 0.009). There’s statistically no significant association between dose-duration of cigarette smoking and the CRC risk however we find those who smoked over 30 years and had more than 20 cigarettes / day had higher OR of 1.92 compared to 1.42 of developing CRC in non-smokers. The cessation of smoking for 30 years could eventually reduce the OR to 1.13 closer to the baseline of non-smokers however again the data is statistically non significant. Conclusion: We report a positive association of CRC risk in current smokers among our local population at Hospital Universiti Sains Malaysia in Kelantan with heavy smokers having a higher incidence of rectal cancer. The link between smoking and CRC is important in view of the high incidence of CRC in our country and the ever increasing number of smokers and in view of smoking as a modifiable risk. These findings may be use in educating the public on smoking cessation and also helping healthcare providers in screening patients in the high risk group for early detection of CRC. It also provides us with more local data on which is still very few and a role in future studies. Keywords: Cigarette smoking, colorectal cancer, case-control study. 2014 Thesis http://eprints.usm.my/39373/ http://eprints.usm.my/39373/1/Dr_Lee_Euxian_%28_General_Surgery%29-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC254-282 Neoplasms Tumors Oncology (including Cancer)
spellingShingle	RC254-282 Neoplasms Tumors Oncology (including Cancer) Euxian, Lee A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
description	Background: There have been inconsistent findings in the association between colorectal cancer and smoking exposure. Most reported data were from western population groups with only few involving Asian population while there’re no available local data from Malaysia. As the causes of colorectal cancer are multifactorial, the genetic susceptibility, lifestyle and diet difference between Western and Asian population may be important in determining the overall individual risks across the world. Methods: This study investigates such association in our local population at Hospital Universiti Sains Malaysia in Kelantan. Our case-control study involves patients diagnosed with colorectal cancer from 2005 till 2011 which is matched to a group of controls without the tumour. Data were collected from the patients file records and supplemented further by phone interviews or clinic follow up to complete the validated study proforma. We included a total of 92 cases matched with 92 controls. Results: Current regular smokers have an overall significant association and increased risk of developing CRC (OR = 2.26: CI 95% 0.90-5.89). Increasing number of cigarettes smoked per day is related towards higher rectal cancer risk as compared to colon cancer (p value 0.009). There’s statistically no significant association between dose-duration of cigarette smoking and the CRC risk however we find those who smoked over 30 years and had more than 20 cigarettes / day had higher OR of 1.92 compared to 1.42 of developing CRC in non-smokers. The cessation of smoking for 30 years could eventually reduce the OR to 1.13 closer to the baseline of non-smokers however again the data is statistically non significant. Conclusion: We report a positive association of CRC risk in current smokers among our local population at Hospital Universiti Sains Malaysia in Kelantan with heavy smokers having a higher incidence of rectal cancer. The link between smoking and CRC is important in view of the high incidence of CRC in our country and the ever increasing number of smokers and in view of smoking as a modifiable risk. These findings may be use in educating the public on smoking cessation and also helping healthcare providers in screening patients in the high risk group for early detection of CRC. It also provides us with more local data on which is still very few and a role in future studies. Keywords: Cigarette smoking, colorectal cancer, case-control study.
format	Thesis
qualification_level	Master's degree
author	Euxian, Lee
author_facet	Euxian, Lee
author_sort	Euxian, Lee
title	A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
title_short	A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
title_full	A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
title_fullStr	A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
title_full_unstemmed	A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia
title_sort	case control study on relationship of colorectal cancer and smoking exposure in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2014
url	http://eprints.usm.my/39373/1/Dr_Lee_Euxian_%28_General_Surgery%29-24_pages.pdf
_version_	1747820744697446400

A case control study on relationship of colorectal cancer and smoking exposure in Hospital Universiti Sains Malaysia

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