Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers

Elevated oxidative stress, inflammation and alteration in lipid profiles in smokers have been proposed as among the major factors that contribute to the development of smoking-related cardiovascular disease. However, the possible beneficial effect of Tualang honey that has antioxidant, anti-inflamma...

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Main Author:	Wan Ghazali, Wan Syaheedah
Format:	Thesis
Language:	English
Published:	2014
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/39715/1/Dr._Wan_Syaheedah_Wan_Ghazali-24_pages.pdf
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spelling	my-usm-ep.397152019-04-12T05:26:08Z Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers 2014 Wan Ghazali, Wan Syaheedah R735-854 Medical education. Medical schools. Research Elevated oxidative stress, inflammation and alteration in lipid profiles in smokers have been proposed as among the major factors that contribute to the development of smoking-related cardiovascular disease. However, the possible beneficial effect of Tualang honey that has antioxidant, anti-inflammatory and antilipid properties among smokers has yet been reported. The aims of this study, therefore, to determine the effects of Tualang Honey supplementation on oxidative stress markers, inflammatory markers and lipid profiles in smokers. A total of 36 non smokers and 72 smokers were recruited. The smokers were then randomly divided into 2 groups namely smokers without supplementation and smokers with honey supplementation at the dose of 20 gram/day for 12 weeks. Blood was obtained for determination of oxidative stress markers, inflammatory markers and lipid profiles from all groups at pre-intervention and from smokers group at post-intervention. At pre-intervention, smokers had significantly higher levels of F2-isoprostanes, total antioxidant status (TAS) and catalase (CAT) activity compared to non smokers. Meanwhile, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were significantly lower in smokers than non smokers. A significantly higher level of high sensitivity C-reactive protein (hsCRP) was found in smokers compared to non smokers. However, no significant differences were found for the levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Furthermore, significantly lower high-density lipoprotein (HDL) as well as higher total cholesterol (TC), low-density lipoprotein (LDL) and triglyceride (TG) levels were observed in smokers compared to non smokers. In smokers, Tualang honey supplementation significantly decreased the level of F2-isoprostanes as well as increased the levels/activities of TAS, CAT and GPx. Tualang honey also significantly increased the level of TNF-α and decreased the level of hsCRP. Apart from that, Tualang honey significantly decreased the levels of TC and LDL. These observations might suggest a beneficial effect of Tualang honey against cigarette smoke-induced oxidative stress, inflammation as well as alteration in lipid profiles among smokers which may provide an effect in reducing the atherothrombosis formation and subsequent risk of cardiovascular disease. These beneficial effects could be, partly attributed to its various components which include phenolic acids and flavonoid compounds that have antioxidant, anti-inflammatory and antilipid properties. However, further studies are required to elucidate the exact mechanism of action on these benefical effects of Tualang honey 2014 Thesis http://eprints.usm.my/39715/ http://eprints.usm.my/39715/1/Dr._Wan_Syaheedah_Wan_Ghazali-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Wan Ghazali, Wan Syaheedah Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
description	Elevated oxidative stress, inflammation and alteration in lipid profiles in smokers have been proposed as among the major factors that contribute to the development of smoking-related cardiovascular disease. However, the possible beneficial effect of Tualang honey that has antioxidant, anti-inflammatory and antilipid properties among smokers has yet been reported. The aims of this study, therefore, to determine the effects of Tualang Honey supplementation on oxidative stress markers, inflammatory markers and lipid profiles in smokers. A total of 36 non smokers and 72 smokers were recruited. The smokers were then randomly divided into 2 groups namely smokers without supplementation and smokers with honey supplementation at the dose of 20 gram/day for 12 weeks. Blood was obtained for determination of oxidative stress markers, inflammatory markers and lipid profiles from all groups at pre-intervention and from smokers group at post-intervention. At pre-intervention, smokers had significantly higher levels of F2-isoprostanes, total antioxidant status (TAS) and catalase (CAT) activity compared to non smokers. Meanwhile, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were significantly lower in smokers than non smokers. A significantly higher level of high sensitivity C-reactive protein (hsCRP) was found in smokers compared to non smokers. However, no significant differences were found for the levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Furthermore, significantly lower high-density lipoprotein (HDL) as well as higher total cholesterol (TC), low-density lipoprotein (LDL) and triglyceride (TG) levels were observed in smokers compared to non smokers. In smokers, Tualang honey supplementation significantly decreased the level of F2-isoprostanes as well as increased the levels/activities of TAS, CAT and GPx. Tualang honey also significantly increased the level of TNF-α and decreased the level of hsCRP. Apart from that, Tualang honey significantly decreased the levels of TC and LDL. These observations might suggest a beneficial effect of Tualang honey against cigarette smoke-induced oxidative stress, inflammation as well as alteration in lipid profiles among smokers which may provide an effect in reducing the atherothrombosis formation and subsequent risk of cardiovascular disease. These beneficial effects could be, partly attributed to its various components which include phenolic acids and flavonoid compounds that have antioxidant, anti-inflammatory and antilipid properties. However, further studies are required to elucidate the exact mechanism of action on these benefical effects of Tualang honey
format	Thesis
qualification_level	Master's degree
author	Wan Ghazali, Wan Syaheedah
author_facet	Wan Ghazali, Wan Syaheedah
author_sort	Wan Ghazali, Wan Syaheedah
title	Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
title_short	Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
title_full	Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
title_fullStr	Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
title_full_unstemmed	Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
title_sort	effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2014
url	http://eprints.usm.my/39715/1/Dr._Wan_Syaheedah_Wan_Ghazali-24_pages.pdf
_version_	1747820766719639552

Effects of tualang honey supplementation on oxidative stress status, inflammation and lipid profiles in chronic smokers

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