Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension

Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reacti...

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Main Author:	Suhaimi, Farah Wahida
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf
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id	my-usm-ep.41231
record_format	uketd_dc
spelling	my-usm-ep.412312019-04-12T05:26:47Z Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension 2010-10 Suhaimi, Farah Wahida RS1-441 Pharmacy and materia medica Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reactivity in obesity-induced hypertension. Male Sprague-Dawley rats were fed with low-fat diet or moderately high-fat (MHF) diet for 16 weeks. Then, rats on MHF diet were segregated into obesity-prone (OP) and obesity-resistant (OR) rats based on the body weight distribution. OR rats were defined as rats with body weight similar or less than control rats (LF rats) while OP rats were defined as rats with greatest body weight. At week 16, rats were subjected to study the role of EAA on RVLM neurons or to study the peripheral vascular reactivity in obesity-induced hypertension. In the former study, L-glutamate (1 nmol) and kynurenic acid (KYN) at concentrations of 4 nM, 40 nM and 4 μM were microinjected into RVLM and hexamethonium (20 mg/kg) was administered intravenously. Brain stem was removed for histological verification and adiposity index was calculated. OP rats exhibited significantly larger weight gain, higher adiposity index and also elevated blood pressure. 2010-10 Thesis http://eprints.usm.my/41231/ http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Suhaimi, Farah Wahida Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
description	Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reactivity in obesity-induced hypertension. Male Sprague-Dawley rats were fed with low-fat diet or moderately high-fat (MHF) diet for 16 weeks. Then, rats on MHF diet were segregated into obesity-prone (OP) and obesity-resistant (OR) rats based on the body weight distribution. OR rats were defined as rats with body weight similar or less than control rats (LF rats) while OP rats were defined as rats with greatest body weight. At week 16, rats were subjected to study the role of EAA on RVLM neurons or to study the peripheral vascular reactivity in obesity-induced hypertension. In the former study, L-glutamate (1 nmol) and kynurenic acid (KYN) at concentrations of 4 nM, 40 nM and 4 μM were microinjected into RVLM and hexamethonium (20 mg/kg) was administered intravenously. Brain stem was removed for histological verification and adiposity index was calculated. OP rats exhibited significantly larger weight gain, higher adiposity index and also elevated blood pressure.
format	Thesis
qualification_level	Master's degree
author	Suhaimi, Farah Wahida
author_facet	Suhaimi, Farah Wahida
author_sort	Suhaimi, Farah Wahida
title	Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_short	Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_full	Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_fullStr	Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_full_unstemmed	Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_sort	study on role of excitatory amino acid input on rostral ventrolateral medulla neurons and assessment of peripheral vascular reactivity in obesity-induced hypertension
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2010
url	http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf
_version_	1747820891988819968

Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension

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