Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions

The present study focuses on two topics that are related to volume expansion (VE); investigating the effect of atrial natriuretic peptide (ANP) and pregnancy-induced changes, in the regulation of the cardiovascular functions. ANP is released from the cardiac atria in response to hypervolemic state....

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Main Author:	Yusoff, Nurul Hasnida Mohammad
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/41237/1/Nurul_Hasnida_Binti_Mohammad_Yusoff-shahfiq.pdf
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id	my-usm-ep.41237
record_format	uketd_dc
spelling	my-usm-ep.412372018-08-06T07:44:43Z Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions 2010-09 Yusoff, Nurul Hasnida Mohammad RS1-441 Pharmacy and materia medica The present study focuses on two topics that are related to volume expansion (VE); investigating the effect of atrial natriuretic peptide (ANP) and pregnancy-induced changes, in the regulation of the cardiovascular functions. ANP is released from the cardiac atria in response to hypervolemic state. Even though its role during VE is well established, the central mechanism underlying its systemic effect is less studied. Therefore, this study sets out to examine the systemic and central effect of ANP, as well as the involvement of supraspinal vasopressin pathways in mediating the effect produced by intravenous ANP. Our findings show that the systemic administration of low and high doses of ANP in urethane-anaesthetized male Sprague-Dawley rats produce a significant renal sympathoinhibition, vasodilation and bradycardia, and these effects are dependent on the efficacy of a well established supraspinal vasopressin pathway. 2010-09 Thesis http://eprints.usm.my/41237/ http://eprints.usm.my/41237/1/Nurul_Hasnida_Binti_Mohammad_Yusoff-shahfiq.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Yusoff, Nurul Hasnida Mohammad Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
description	The present study focuses on two topics that are related to volume expansion (VE); investigating the effect of atrial natriuretic peptide (ANP) and pregnancy-induced changes, in the regulation of the cardiovascular functions. ANP is released from the cardiac atria in response to hypervolemic state. Even though its role during VE is well established, the central mechanism underlying its systemic effect is less studied. Therefore, this study sets out to examine the systemic and central effect of ANP, as well as the involvement of supraspinal vasopressin pathways in mediating the effect produced by intravenous ANP. Our findings show that the systemic administration of low and high doses of ANP in urethane-anaesthetized male Sprague-Dawley rats produce a significant renal sympathoinhibition, vasodilation and bradycardia, and these effects are dependent on the efficacy of a well established supraspinal vasopressin pathway.
format	Thesis
qualification_level	Master's degree
author	Yusoff, Nurul Hasnida Mohammad
author_facet	Yusoff, Nurul Hasnida Mohammad
author_sort	Yusoff, Nurul Hasnida Mohammad
title	Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
title_short	Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
title_full	Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
title_fullStr	Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
title_full_unstemmed	Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
title_sort	effects of atrial natriuretic peptide and pregnancy on the central and peripheral regulation of the cardiovascular functions
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2010
url	http://eprints.usm.my/41237/1/Nurul_Hasnida_Binti_Mohammad_Yusoff-shahfiq.pdf
_version_	1747820892970287104

Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions

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