Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children

Background Optic nerve head (ONH) parameters and retinal nerve fiber layer thickness (RNFLT) of normal children have been described in previous published reports. None of these measurements was described among Malay children population using Cirrus spectral domain optical coherence tomography (S...

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Main Author:	Ahmad, Ameilia
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/41391/1/Dr._Ameilia_Ahmad-24_pages1.pdf
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spelling	my-usm-ep.413912019-04-12T05:25:28Z Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children 2016 Ahmad, Ameilia RE Ophthalmology Background Optic nerve head (ONH) parameters and retinal nerve fiber layer thickness (RNFLT) of normal children have been described in previous published reports. None of these measurements was described among Malay children population using Cirrus spectral domain optical coherence tomography (SD-OCT). The aim was to report normative values for ONH parameters and RNFLT in emmetropic Malay children. The possible correlations between these parameters were also evaluated. Objectives To determine the mean of ONH parameters and mean RNFL in emmetropic Malay children; and to determine correlation between the ONH parameters and RNFL thickness Methods Ninety-five Malay children with no ocular abnormality aged between 7 to 17 years were recruited into this cross sectional study. It was conducted in Hospital Universiti Sains Malaysia, Malaysia from January 2014 to December 2015. All children underwent a complete ocular examination including refraction and axial length measurement. ONH parameters and RNFLT measurement were performed using Cirrus SD-OCT machine. One eye of each subject was randomly selected for analysis. The correlations in between the parameters and influence of age, gender,axial length and spherical equivalent (SE) on measurements were statistically evaluated. Results Ninety-five children were included in the study with 65 females (68.4%) and 30 males (31.6%). Mean age was 10.6 (2.82) years, mean IOP was 14.8 (2.81) mmHg, mean SE refraction was -0.12 (0.28) diopters and mean axial length was 23.03 (0.76) mm. Mean (SD) disc area, rim area and cup volume were 2.32 (0.40) mm2, 1.53 (0.33) mm2 and 0.204 (0.16) mm3, respectively. The average cup to disc ratio (SD) and vertical CDR were 0.55 (0.13) and 0.50 (0.14). Mean (SD) RNFLT for all patients was 102.08 (11.08) μm. The average, superior and inferior RNFLT showed a significant positive correlation with the optic disc area. A significant correlation was also observed between the rim area and average, superior, inferior and nasal RNFLT. The inferior RNFLT was negatively correlated with average CDR. There was also significant effect of gender on disc area. There were no significant effects of age, axial length and SE on the measurements. Conclusion This study provides normative data of ONH parameters and RNFLT in emmetropic Malay children. Emmetropic Malay male had a significantly larger optic disc area. Increase in RNFLT is associated with significant increase in disc and rim areas. 2016 Thesis http://eprints.usm.my/41391/ http://eprints.usm.my/41391/1/Dr._Ameilia_Ahmad-24_pages1.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Ahmad, Ameilia Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
description	Background Optic nerve head (ONH) parameters and retinal nerve fiber layer thickness (RNFLT) of normal children have been described in previous published reports. None of these measurements was described among Malay children population using Cirrus spectral domain optical coherence tomography (SD-OCT). The aim was to report normative values for ONH parameters and RNFLT in emmetropic Malay children. The possible correlations between these parameters were also evaluated. Objectives To determine the mean of ONH parameters and mean RNFL in emmetropic Malay children; and to determine correlation between the ONH parameters and RNFL thickness Methods Ninety-five Malay children with no ocular abnormality aged between 7 to 17 years were recruited into this cross sectional study. It was conducted in Hospital Universiti Sains Malaysia, Malaysia from January 2014 to December 2015. All children underwent a complete ocular examination including refraction and axial length measurement. ONH parameters and RNFLT measurement were performed using Cirrus SD-OCT machine. One eye of each subject was randomly selected for analysis. The correlations in between the parameters and influence of age, gender,axial length and spherical equivalent (SE) on measurements were statistically evaluated. Results Ninety-five children were included in the study with 65 females (68.4%) and 30 males (31.6%). Mean age was 10.6 (2.82) years, mean IOP was 14.8 (2.81) mmHg, mean SE refraction was -0.12 (0.28) diopters and mean axial length was 23.03 (0.76) mm. Mean (SD) disc area, rim area and cup volume were 2.32 (0.40) mm2, 1.53 (0.33) mm2 and 0.204 (0.16) mm3, respectively. The average cup to disc ratio (SD) and vertical CDR were 0.55 (0.13) and 0.50 (0.14). Mean (SD) RNFLT for all patients was 102.08 (11.08) μm. The average, superior and inferior RNFLT showed a significant positive correlation with the optic disc area. A significant correlation was also observed between the rim area and average, superior, inferior and nasal RNFLT. The inferior RNFLT was negatively correlated with average CDR. There was also significant effect of gender on disc area. There were no significant effects of age, axial length and SE on the measurements. Conclusion This study provides normative data of ONH parameters and RNFLT in emmetropic Malay children. Emmetropic Malay male had a significantly larger optic disc area. Increase in RNFLT is associated with significant increase in disc and rim areas.
format	Thesis
qualification_level	Master's degree
author	Ahmad, Ameilia
author_facet	Ahmad, Ameilia
author_sort	Ahmad, Ameilia
title	Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
title_short	Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
title_full	Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
title_fullStr	Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
title_full_unstemmed	Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children
title_sort	optic nerve head and retinal nerve fiber layer analysis in emmetropic malay children
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/41391/1/Dr._Ameilia_Ahmad-24_pages1.pdf
_version_	1747820921827098624

Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children

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