Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery

Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosa...

Full description

Saved in:

Bibliographic Details
Main Author:	Lim , Vuanghao
Format:	Thesis
Language:	English
Published:	2009
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.41554
record_format	uketd_dc
spelling	my-usm-ep.415542019-04-12T05:26:59Z Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery 2009-12 Lim , Vuanghao RS1-441 Pharmacy and materia medica Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosaj yang diformulasikan mesti melalui saluran pencernaan bahagian atas dalam bentuk utuh sebelum penghantaran drug kepada kolon. Penggunaan polimer disulfida sebagai satu penghantaran responsif bakteria merupakan salah satu strategi untuk menyasarkan drug kepada kolon bagi melepaskan drug secara khusus dalam kolon. Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon. 2009-12 Thesis http://eprints.usm.my/41554/ http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Lim , Vuanghao Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
description	Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosaj yang diformulasikan mesti melalui saluran pencernaan bahagian atas dalam bentuk utuh sebelum penghantaran drug kepada kolon. Penggunaan polimer disulfida sebagai satu penghantaran responsif bakteria merupakan salah satu strategi untuk menyasarkan drug kepada kolon bagi melepaskan drug secara khusus dalam kolon. Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Lim , Vuanghao
author_facet	Lim , Vuanghao
author_sort	Lim , Vuanghao
title	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
title_short	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
title_full	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
title_fullStr	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
title_full_unstemmed	Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
title_sort	synthesis and evaluation of cross-linked disulphide containing polymers for colonic drug delivery
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2009
url	http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf
_version_	1747820930885746688

Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery

Similar Items