The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia

Background : Patients with renal colic usually presented to Emergency Department with severe and excruciating pain. Emergency Physicians using numerous medications to treat the problem, however none of them had been proven to relieve the pain completely. This study aimed to compare the effectiven...

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Main Author:	Ismail, Azirawati
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RM Therapeutics Pharmacology
Online Access:	http://eprints.usm.my/41614/1/Dr._Azirawati_Ismail-24_pages.pdf
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spelling	my-usm-ep.416142019-04-12T05:25:29Z The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia 2016 Ismail, Azirawati RM Therapeutics. Pharmacology Background : Patients with renal colic usually presented to Emergency Department with severe and excruciating pain. Emergency Physicians using numerous medications to treat the problem, however none of them had been proven to relieve the pain completely. This study aimed to compare the effectiveness of IV parecoxib versus IV morphine in suspected acute renal colic in Emergency Department . Objectives : The objectives of this study were comparison between IV parecoxib sodium and morphine in Emergenency Department HUSM regarding pain score reduction among acute renal colic patient over time, mean pain score reduction by group over time and to compare the effectiveness of both analgesics (reduction by 2 pain scores) after 5 minutes of drug administration. The side effects of both drugs will be evaluated too. Methods : A randomized, single-blinded study comparing IV parecoxib 40 mg versus IV morphine at 0.10 mg/kg was conducted in adult patients who presented with features suggestive of acute renal colic and NRS of 6 or more. Periodic assessment of vital signs and NRS were taken at 0, 5, 15 and 30 minutes as well as evaluation of side effects within 30 minutes after the administration of the study drugs. The primary outcome was the reduction of NRS. The data was analyzed by repeated measures ANOVA analysis. Results : There was no significant difference in the mean NRS between patients in IV parecoxib group and morphine group over time (F(3,126)=0.229, P=0.876). Comparison of the effectiveness at 5 minutes between the groups was not significant (P=0.498). Dizziness, vomiting and nausea were experienced in 22.7%, 13.6% and4.5% of patients respectively in IV morphine group as compared to parecoxib group 4.5% experienced of nausea only. Conclusions : There was no significant difference in NRS between the groups over time, as well as in term of the effectiveness at 5 minutes. Due to lack of IV parecoxib side effect compared to morphine, IV parecoxib seemed to be valuable in the future and can be used as analgesic alternative to morphine in acute renal colic as well as extended further to treat a variety of cases presented in ED HUSM. 2016 Thesis http://eprints.usm.my/41614/ http://eprints.usm.my/41614/1/Dr._Azirawati_Ismail-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM Therapeutics Pharmacology
spellingShingle	RM Therapeutics Pharmacology Ismail, Azirawati The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
description	Background : Patients with renal colic usually presented to Emergency Department with severe and excruciating pain. Emergency Physicians using numerous medications to treat the problem, however none of them had been proven to relieve the pain completely. This study aimed to compare the effectiveness of IV parecoxib versus IV morphine in suspected acute renal colic in Emergency Department . Objectives : The objectives of this study were comparison between IV parecoxib sodium and morphine in Emergenency Department HUSM regarding pain score reduction among acute renal colic patient over time, mean pain score reduction by group over time and to compare the effectiveness of both analgesics (reduction by 2 pain scores) after 5 minutes of drug administration. The side effects of both drugs will be evaluated too. Methods : A randomized, single-blinded study comparing IV parecoxib 40 mg versus IV morphine at 0.10 mg/kg was conducted in adult patients who presented with features suggestive of acute renal colic and NRS of 6 or more. Periodic assessment of vital signs and NRS were taken at 0, 5, 15 and 30 minutes as well as evaluation of side effects within 30 minutes after the administration of the study drugs. The primary outcome was the reduction of NRS. The data was analyzed by repeated measures ANOVA analysis. Results : There was no significant difference in the mean NRS between patients in IV parecoxib group and morphine group over time (F(3,126)=0.229, P=0.876). Comparison of the effectiveness at 5 minutes between the groups was not significant (P=0.498). Dizziness, vomiting and nausea were experienced in 22.7%, 13.6% and4.5% of patients respectively in IV morphine group as compared to parecoxib group 4.5% experienced of nausea only. Conclusions : There was no significant difference in NRS between the groups over time, as well as in term of the effectiveness at 5 minutes. Due to lack of IV parecoxib side effect compared to morphine, IV parecoxib seemed to be valuable in the future and can be used as analgesic alternative to morphine in acute renal colic as well as extended further to treat a variety of cases presented in ED HUSM.
format	Thesis
qualification_level	Master's degree
author	Ismail, Azirawati
author_facet	Ismail, Azirawati
author_sort	Ismail, Azirawati
title	The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
title_short	The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
title_full	The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
title_fullStr	The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
title_full_unstemmed	The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia
title_sort	effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in emergency department hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/41614/1/Dr._Azirawati_Ismail-24_pages.pdf
_version_	1747820940483362816

The effectiveness of intravenous parecoxib sodium as an analgesic alternative to morphine in suspected acute renal colic in Emergency Department Hospital Universiti Sains Malaysia

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