Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan

Introduction: End Stage of Renal Disease (ESRD) in Chronic Kidney Disease (CKD) patients represents a heavy burden for patients, families, and health care systems. Objectives: The objectives of this study were to determine the renal survival time of CKD patients at Hospital USM and to identify th...

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Main Author:	Omar, Fatin Farhanah Haji
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC870-923 Diseases of the genitourinary system Urology
Online Access:	http://eprints.usm.my/41813/1/Dr._Fatin_Farhanah_Haji_Omar-24_pages.pdf
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id	my-usm-ep.41813
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spelling	my-usm-ep.418132019-04-12T05:25:21Z Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan 2016-04 Omar, Fatin Farhanah Haji RC870-923 Diseases of the genitourinary system. Urology Introduction: End Stage of Renal Disease (ESRD) in Chronic Kidney Disease (CKD) patients represents a heavy burden for patients, families, and health care systems. Objectives: The objectives of this study were to determine the renal survival time of CKD patients at Hospital USM and to identify the prognostic factors that influence the renal survival of patients. Methodology: A retrospective cohort study was conducted involving 247 CKD patients at Hospital USM, Kelantan from January 2005 until December 2015. All patients who fulfilled the criteria were included in the study. The medical record were reviewed and the renal survival time based on the time of the first date of diagnosis with CKD until the the first date of diagnosis with ESRD or received dialysis. The Kaplan-Meier and Cox proportional hazard regression analyses were used in the statistical analysis. Results: Overall renal survival time of CKD patients was 26 months. The significant prognostic factors that influence the renal survival of CKD patients were GFR (adjusted hazard ratio (HR)=0.96, 95% confidence interval (CI): 0.98,0.99; p value <0.001), smoking status (adjusted HR=2.19, 95% CI: 1.53, 3.13; p value=0.042), comorbid hyperlipidemia (adjusted HR=1.87, 95% CI: 1.34,2.60; p value =0.005), analgesics (adjusted HR=1.87, 95% CI: 1.21,2.88; p value =0.015), functional GI disorder (adjusted HR=1.42, 95% CI:1.07,2.01; p value =0.016), lipid lowering agents (adjusted HR=1.41, 95% CI: 1.02,1.97; p value=0.039), corticosteroid (adjusted HR=2.10, 95% CI: 1.25,3.55; p value =0.005), urea (adjusted HR=1.03, 95% CI: 1.01,1.05; p value <0.001), and creatinine (adjusted HR=0.99, 95% CI: 0.98,1.00; p value =0.005). Conclusion: The medium renal survival time of CKD patients in this study very fast within 26 month. The prognostic factors of renal survival identified were GFR level, smoking status, comorbid hyperlipidemia, analgesics, lipid lowering agents, functional GI disorder, corticosteroid drugs, urea and creatinine are significant to renal survival among CKD patients in Hospital USM. Thus, the clinician can change the clinical management by focus on the factors and slow the progression to ESRD. 2016-04 Thesis http://eprints.usm.my/41813/ http://eprints.usm.my/41813/1/Dr._Fatin_Farhanah_Haji_Omar-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC870-923 Diseases of the genitourinary system Urology
spellingShingle	RC870-923 Diseases of the genitourinary system Urology Omar, Fatin Farhanah Haji Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
description	Introduction: End Stage of Renal Disease (ESRD) in Chronic Kidney Disease (CKD) patients represents a heavy burden for patients, families, and health care systems. Objectives: The objectives of this study were to determine the renal survival time of CKD patients at Hospital USM and to identify the prognostic factors that influence the renal survival of patients. Methodology: A retrospective cohort study was conducted involving 247 CKD patients at Hospital USM, Kelantan from January 2005 until December 2015. All patients who fulfilled the criteria were included in the study. The medical record were reviewed and the renal survival time based on the time of the first date of diagnosis with CKD until the the first date of diagnosis with ESRD or received dialysis. The Kaplan-Meier and Cox proportional hazard regression analyses were used in the statistical analysis. Results: Overall renal survival time of CKD patients was 26 months. The significant prognostic factors that influence the renal survival of CKD patients were GFR (adjusted hazard ratio (HR)=0.96, 95% confidence interval (CI): 0.98,0.99; p value <0.001), smoking status (adjusted HR=2.19, 95% CI: 1.53, 3.13; p value=0.042), comorbid hyperlipidemia (adjusted HR=1.87, 95% CI: 1.34,2.60; p value =0.005), analgesics (adjusted HR=1.87, 95% CI: 1.21,2.88; p value =0.015), functional GI disorder (adjusted HR=1.42, 95% CI:1.07,2.01; p value =0.016), lipid lowering agents (adjusted HR=1.41, 95% CI: 1.02,1.97; p value=0.039), corticosteroid (adjusted HR=2.10, 95% CI: 1.25,3.55; p value =0.005), urea (adjusted HR=1.03, 95% CI: 1.01,1.05; p value <0.001), and creatinine (adjusted HR=0.99, 95% CI: 0.98,1.00; p value =0.005). Conclusion: The medium renal survival time of CKD patients in this study very fast within 26 month. The prognostic factors of renal survival identified were GFR level, smoking status, comorbid hyperlipidemia, analgesics, lipid lowering agents, functional GI disorder, corticosteroid drugs, urea and creatinine are significant to renal survival among CKD patients in Hospital USM. Thus, the clinician can change the clinical management by focus on the factors and slow the progression to ESRD.
format	Thesis
qualification_level	Master's degree
author	Omar, Fatin Farhanah Haji
author_facet	Omar, Fatin Farhanah Haji
author_sort	Omar, Fatin Farhanah Haji
title	Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
title_short	Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
title_full	Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
title_fullStr	Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
title_full_unstemmed	Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan
title_sort	renal survival and its prognostic factors in chronic kidney disease patients in hospital universiti sains malaysia, kelantan
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/41813/1/Dr._Fatin_Farhanah_Haji_Omar-24_pages.pdf
_version_	1747820975399895040

Renal survival and its prognostic factors in chronic kidney disease patients in Hospital Universiti Sains Malaysia, Kelantan

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