Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis

Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the anal...

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Main Author:	Al Azzam, Khaldun Mohammad Mitlaq
Format:	Thesis
Language:	English
Published:	2011
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf
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id	my-usm-ep.41894
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spelling	my-usm-ep.418942019-04-12T05:26:40Z Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis 2011 Al Azzam, Khaldun Mohammad Mitlaq QD1-999 Chemistry Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations. 2011 Thesis http://eprints.usm.my/41894/ http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Al Azzam, Khaldun Mohammad Mitlaq Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
description	Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Al Azzam, Khaldun Mohammad Mitlaq
author_facet	Al Azzam, Khaldun Mohammad Mitlaq
author_sort	Al Azzam, Khaldun Mohammad Mitlaq
title	Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
title_short	Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
title_full	Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
title_fullStr	Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
title_full_unstemmed	Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
title_sort	analytical method development and fundamental studies on the separation of drugs using capillary electrophoresis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2011
url	http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf
_version_	1747820990720638976

Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis

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