Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the anal...
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my-usm-ep.418942019-04-12T05:26:40Z Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis 2011 Al Azzam, Khaldun Mohammad Mitlaq QD1-999 Chemistry Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations. 2011 Thesis http://eprints.usm.my/41894/ http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia |
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Universiti Sains Malaysia |
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English |
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QD1-999 Chemistry |
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QD1-999 Chemistry Al Azzam, Khaldun Mohammad Mitlaq Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
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Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations. |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Al Azzam, Khaldun Mohammad Mitlaq |
author_facet |
Al Azzam, Khaldun Mohammad Mitlaq |
author_sort |
Al Azzam, Khaldun Mohammad Mitlaq |
title |
Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
title_short |
Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
title_full |
Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
title_fullStr |
Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
title_full_unstemmed |
Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
title_sort |
analytical method development and fundamental studies on the separation of drugs using capillary electrophoresis |
granting_institution |
Universiti Sains Malaysia |
granting_department |
Pusat Pengajian Sains Kimia |
publishDate |
2011 |
url |
http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf |
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1747820990720638976 |