Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes

The underlying changes in the neuronal connectivity adjacent to brain tumours cannot always be depicted by conventional MR imaging. The hypothesis of this study was that preoperative neuropsychological deficits are associated with impairment of diffusivity in association fibre bundles. Hence, we inv...

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Main Author:	Hooi, Lim Liang
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/42021/1/Dr._Lim_Liang_Hoii-24_pages.pdf
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spelling	my-usm-ep.420212019-04-12T05:25:29Z Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes 2016 Hooi, Lim Liang RC Internal medicine The underlying changes in the neuronal connectivity adjacent to brain tumours cannot always be depicted by conventional MR imaging. The hypothesis of this study was that preoperative neuropsychological deficits are associated with impairment of diffusivity in association fibre bundles. Hence, we investigated the potential of combined diffusion tensor imaging (DTI) fibre tracking and fractional anisotropy (FA) values of the fibres to determine changes in association fibres and their correlation to neuropsychological scores. Our study consisted of eighteen patients with extra-axial brain tumours in areas adjacent to the frontal and temporal lobes. They were assessed pre-and postoperatively with DTI and neuropsychological assessments. MR examinations were performed on a 3T-scanner. FA values were calculated for the uncinate fasciculus, arcuate fasciculus, superior fronto-occipital fasciculus, inferior fronto-occipital fasciculus and corticospinal tracts ipsilateral and contralateral to the tumor. These values were compared with neuropsychological scores for language, memory and attention. The analysis revealed marked differences in pre- and post-excision of the tumor in both FA values and neuropsychological scores. Quantitative DTI was able to show significant differences in diffusivity of the association fibres before and after the surgery. The additional use of DTI-fibre integrity and neuropsychological tests may aid in prognostication and decision making prior to surgery. 2016 Thesis http://eprints.usm.my/42021/ http://eprints.usm.my/42021/1/Dr._Lim_Liang_Hoii-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Hooi, Lim Liang Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
description	The underlying changes in the neuronal connectivity adjacent to brain tumours cannot always be depicted by conventional MR imaging. The hypothesis of this study was that preoperative neuropsychological deficits are associated with impairment of diffusivity in association fibre bundles. Hence, we investigated the potential of combined diffusion tensor imaging (DTI) fibre tracking and fractional anisotropy (FA) values of the fibres to determine changes in association fibres and their correlation to neuropsychological scores. Our study consisted of eighteen patients with extra-axial brain tumours in areas adjacent to the frontal and temporal lobes. They were assessed pre-and postoperatively with DTI and neuropsychological assessments. MR examinations were performed on a 3T-scanner. FA values were calculated for the uncinate fasciculus, arcuate fasciculus, superior fronto-occipital fasciculus, inferior fronto-occipital fasciculus and corticospinal tracts ipsilateral and contralateral to the tumor. These values were compared with neuropsychological scores for language, memory and attention. The analysis revealed marked differences in pre- and post-excision of the tumor in both FA values and neuropsychological scores. Quantitative DTI was able to show significant differences in diffusivity of the association fibres before and after the surgery. The additional use of DTI-fibre integrity and neuropsychological tests may aid in prognostication and decision making prior to surgery.
format	Thesis
qualification_level	Master's degree
author	Hooi, Lim Liang
author_facet	Hooi, Lim Liang
author_sort	Hooi, Lim Liang
title	Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
title_short	Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
title_full	Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
title_fullStr	Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
title_full_unstemmed	Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
title_sort	preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42021/1/Dr._Lim_Liang_Hoii-24_pages.pdf
_version_	1747821014739320832

Preoperative and postoperative diffusion tensor imaging in patients with extra-axial lesions at the frontal or temporal regions of the brain and their correlations with neuropsychological outcomes

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