An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction

INTRODUCTION: Premature ejaculation (PE) causes reduces sexual satisfaction and quality of life. Both Selective Serotonin Re-uptake Inhibitor Fluoxetine and Dapoxetine have been used in treatment of PE. Fluoxetine is used as off-label treatment meanwhile Dapoxetine is the first SSRI specifically des...

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Main Author:	Man, Mohamad Hj Che'
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/42328/1/Dr._Mohamad_Hj_Che_Man-24_pages.pdf
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spelling	my-usm-ep.423282019-04-12T05:25:31Z An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction 2016 Man, Mohamad Hj Che' RC31-1245 Internal medicine INTRODUCTION: Premature ejaculation (PE) causes reduces sexual satisfaction and quality of life. Both Selective Serotonin Re-uptake Inhibitor Fluoxetine and Dapoxetine have been used in treatment of PE. Fluoxetine is used as off-label treatment meanwhile Dapoxetine is the first SSRI specifically designed for PE that has a short half-life and few side effects. OBJECTIVES: To compare the PE symptoms score and marital satisfaction score between Fluoxetine and Dapoxetine groups. METHODS: In this open labelled randomized clinical trial, 44 participants aged between 18 and 64 with PEDT score of ≥ 9 from the Primary Care clinic of Hospital USM, Kelantan Malaysia were recruited and randomized into two groups; Fluoxetine Group (FG) and Dapoxetine Group (DG). They were prescribed with either daily oral Fluoxetine 20mg or Dapoxetine 30mg on demand twice weekly for 8 weeks. PE symptoms were measured using the Premature Ejaculation Diagnostics Tool (PEDT) score and marital satisfaction score were measured using the Dyadic Satisfaction-Dyadic Adjustment Scale (DS-DAS) score. Measurements were made at baseline and at the 8th week (post intervention). RESULTS: In FG and DG, 22 and 21 participants completed the study, respectively. PEDT scores reduced significantly within both groups [from 11.41 to 5.45 (P<0.001) within FG and from 13.43 to 3.10 (P<0.001) within the DG]. At the 8th week follow-up, PEDT scores was observed to be were lower in DG (6.03 vs. 2.49, P<0.001) after adjustment of the baseline PEDT score. Significantly increased DS-DAS scores were observed in both groups [from34.50 to 40.68 (P<0.001) within FG and from 36.57 to 44.33, (P<0.001) within DG] with no significant difference in DS-DAS scores at the end of study (41.13 vs. 43.86, P=0.055) after adjustment of the baseline DS-DAS score. CONCLUSIONS: Reduction in PE symptoms was observed for both groups. At 8 weeks, PE symptoms among participants on Dapoxetine were significantly lower compared to the participants on Fluoxetine group at 8 weeks. Treatment of PE with either Fluoxetine or Dapoxetine reduces symptoms of PE and improves marital satisfaction. 2016 Thesis http://eprints.usm.my/42328/ http://eprints.usm.my/42328/1/Dr._Mohamad_Hj_Che_Man-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Man, Mohamad Hj Che' An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
description	INTRODUCTION: Premature ejaculation (PE) causes reduces sexual satisfaction and quality of life. Both Selective Serotonin Re-uptake Inhibitor Fluoxetine and Dapoxetine have been used in treatment of PE. Fluoxetine is used as off-label treatment meanwhile Dapoxetine is the first SSRI specifically designed for PE that has a short half-life and few side effects. OBJECTIVES: To compare the PE symptoms score and marital satisfaction score between Fluoxetine and Dapoxetine groups. METHODS: In this open labelled randomized clinical trial, 44 participants aged between 18 and 64 with PEDT score of ≥ 9 from the Primary Care clinic of Hospital USM, Kelantan Malaysia were recruited and randomized into two groups; Fluoxetine Group (FG) and Dapoxetine Group (DG). They were prescribed with either daily oral Fluoxetine 20mg or Dapoxetine 30mg on demand twice weekly for 8 weeks. PE symptoms were measured using the Premature Ejaculation Diagnostics Tool (PEDT) score and marital satisfaction score were measured using the Dyadic Satisfaction-Dyadic Adjustment Scale (DS-DAS) score. Measurements were made at baseline and at the 8th week (post intervention). RESULTS: In FG and DG, 22 and 21 participants completed the study, respectively. PEDT scores reduced significantly within both groups [from 11.41 to 5.45 (P<0.001) within FG and from 13.43 to 3.10 (P<0.001) within the DG]. At the 8th week follow-up, PEDT scores was observed to be were lower in DG (6.03 vs. 2.49, P<0.001) after adjustment of the baseline PEDT score. Significantly increased DS-DAS scores were observed in both groups [from34.50 to 40.68 (P<0.001) within FG and from 36.57 to 44.33, (P<0.001) within DG] with no significant difference in DS-DAS scores at the end of study (41.13 vs. 43.86, P=0.055) after adjustment of the baseline DS-DAS score. CONCLUSIONS: Reduction in PE symptoms was observed for both groups. At 8 weeks, PE symptoms among participants on Dapoxetine were significantly lower compared to the participants on Fluoxetine group at 8 weeks. Treatment of PE with either Fluoxetine or Dapoxetine reduces symptoms of PE and improves marital satisfaction.
format	Thesis
qualification_level	Master's degree
author	Man, Mohamad Hj Che'
author_facet	Man, Mohamad Hj Che'
author_sort	Man, Mohamad Hj Che'
title	An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
title_short	An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
title_full	An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
title_fullStr	An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
title_full_unstemmed	An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
title_sort	open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42328/1/Dr._Mohamad_Hj_Che_Man-24_pages.pdf
_version_	1747821058243690496

An open labelled randomized clinical trial of fluoxetine versus dapoxetine treatment among men with premature ejaculation and its effect on marital satisfaction

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