Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population

Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpress...

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Main Author: Yusof, Muhd Afif Mohd
Format: Thesis
Language:English
Published: 2016
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Online Access:http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf
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spelling my-usm-ep.423812019-04-12T05:25:27Z Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population 2016 Yusof, Muhd Afif Mohd RG Gynecology and obstetrics Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpressed (HO) and Triple Negative (TN) subtype. The St. Gallen 2011 Classification recognizes the use of Ki67 proliferative index to identify LB subtype from LA group. LB has a worse prognosis and different approach of treatment. Objective: This study aimed to identify HER2 negative LB subtype according to St Gallen Classification 2011 using Ki67 and to compare the clinicopathological features of different subtypes. Methods: Tissue biopsies of LA subtype were stained with antibody towards Ki67. LA cases with Ki67 ≥14% were reclassified as LB subtype. Luminal subtypes with corresponding stage (tumour size), histological grade and lymph node metastases were compared. Univariate analysis using simple logistic regression was performed to determine the percentage of Ki67 expression among all IBC NST cases. McNemar’s test was used for paired categorical analysis. All calculations performed using SPSS version 22 and a pvalue of <0.05 was set to denote statistical significance. Results: LA is the most common subtype (43%; 68/158), followed by LB (33%; 52/158). Only 37 out of 68 cases were stained with Ki67 due to sample limitations. From these LA cases, 43% (16/37) showed Ki67 ≥14% (reclassified as LB subtype). There was significant result when using Ki67 (P<0.001; P<0.05). However, LB subtype showed statistically insignificant result when compared with between stage, grade and lymph node status. Conclusion: The classification according to the St Gallen Classification 2011 utilized Ki67 marker in addition to ER, PR and HER2 in identifying luminal B subtype cases, which have a worse prognosis. 2016 Thesis http://eprints.usm.my/42381/ http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RG Gynecology and obstetrics
spellingShingle RG Gynecology and obstetrics
Yusof, Muhd Afif Mohd
Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
description Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpressed (HO) and Triple Negative (TN) subtype. The St. Gallen 2011 Classification recognizes the use of Ki67 proliferative index to identify LB subtype from LA group. LB has a worse prognosis and different approach of treatment. Objective: This study aimed to identify HER2 negative LB subtype according to St Gallen Classification 2011 using Ki67 and to compare the clinicopathological features of different subtypes. Methods: Tissue biopsies of LA subtype were stained with antibody towards Ki67. LA cases with Ki67 ≥14% were reclassified as LB subtype. Luminal subtypes with corresponding stage (tumour size), histological grade and lymph node metastases were compared. Univariate analysis using simple logistic regression was performed to determine the percentage of Ki67 expression among all IBC NST cases. McNemar’s test was used for paired categorical analysis. All calculations performed using SPSS version 22 and a pvalue of <0.05 was set to denote statistical significance. Results: LA is the most common subtype (43%; 68/158), followed by LB (33%; 52/158). Only 37 out of 68 cases were stained with Ki67 due to sample limitations. From these LA cases, 43% (16/37) showed Ki67 ≥14% (reclassified as LB subtype). There was significant result when using Ki67 (P<0.001; P<0.05). However, LB subtype showed statistically insignificant result when compared with between stage, grade and lymph node status. Conclusion: The classification according to the St Gallen Classification 2011 utilized Ki67 marker in addition to ER, PR and HER2 in identifying luminal B subtype cases, which have a worse prognosis.
format Thesis
qualification_level Master's degree
author Yusof, Muhd Afif Mohd
author_facet Yusof, Muhd Afif Mohd
author_sort Yusof, Muhd Afif Mohd
title Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_short Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_full Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_fullStr Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_full_unstemmed Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_sort classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on ki67 index among sabahan population
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2016
url http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf
_version_ 1747821061436604416