Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population

Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpress...

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Main Author:	Yusof, Muhd Afif Mohd
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf
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spelling	my-usm-ep.423812019-04-12T05:25:27Z Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population 2016 Yusof, Muhd Afif Mohd RG Gynecology and obstetrics Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpressed (HO) and Triple Negative (TN) subtype. The St. Gallen 2011 Classification recognizes the use of Ki67 proliferative index to identify LB subtype from LA group. LB has a worse prognosis and different approach of treatment. Objective: This study aimed to identify HER2 negative LB subtype according to St Gallen Classification 2011 using Ki67 and to compare the clinicopathological features of different subtypes. Methods: Tissue biopsies of LA subtype were stained with antibody towards Ki67. LA cases with Ki67 ≥14% were reclassified as LB subtype. Luminal subtypes with corresponding stage (tumour size), histological grade and lymph node metastases were compared. Univariate analysis using simple logistic regression was performed to determine the percentage of Ki67 expression among all IBC NST cases. McNemar’s test was used for paired categorical analysis. All calculations performed using SPSS version 22 and a pvalue of <0.05 was set to denote statistical significance. Results: LA is the most common subtype (43%; 68/158), followed by LB (33%; 52/158). Only 37 out of 68 cases were stained with Ki67 due to sample limitations. From these LA cases, 43% (16/37) showed Ki67 ≥14% (reclassified as LB subtype). There was significant result when using Ki67 (P<0.001; P<0.05). However, LB subtype showed statistically insignificant result when compared with between stage, grade and lymph node status. Conclusion: The classification according to the St Gallen Classification 2011 utilized Ki67 marker in addition to ER, PR and HER2 in identifying luminal B subtype cases, which have a worse prognosis. 2016 Thesis http://eprints.usm.my/42381/ http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Yusof, Muhd Afif Mohd Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
description	Background: Invasive Breast Carcinoma of No Specific Type (IBC NST) is divided into four subtypes using Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor 2 (HER2) immunohistochemistry markers. They are classified into Luminal A (LA), Luminal B (LB), HER2 Overexpressed (HO) and Triple Negative (TN) subtype. The St. Gallen 2011 Classification recognizes the use of Ki67 proliferative index to identify LB subtype from LA group. LB has a worse prognosis and different approach of treatment. Objective: This study aimed to identify HER2 negative LB subtype according to St Gallen Classification 2011 using Ki67 and to compare the clinicopathological features of different subtypes. Methods: Tissue biopsies of LA subtype were stained with antibody towards Ki67. LA cases with Ki67 ≥14% were reclassified as LB subtype. Luminal subtypes with corresponding stage (tumour size), histological grade and lymph node metastases were compared. Univariate analysis using simple logistic regression was performed to determine the percentage of Ki67 expression among all IBC NST cases. McNemar’s test was used for paired categorical analysis. All calculations performed using SPSS version 22 and a pvalue of <0.05 was set to denote statistical significance. Results: LA is the most common subtype (43%; 68/158), followed by LB (33%; 52/158). Only 37 out of 68 cases were stained with Ki67 due to sample limitations. From these LA cases, 43% (16/37) showed Ki67 ≥14% (reclassified as LB subtype). There was significant result when using Ki67 (P<0.001; P<0.05). However, LB subtype showed statistically insignificant result when compared with between stage, grade and lymph node status. Conclusion: The classification according to the St Gallen Classification 2011 utilized Ki67 marker in addition to ER, PR and HER2 in identifying luminal B subtype cases, which have a worse prognosis.
format	Thesis
qualification_level	Master's degree
author	Yusof, Muhd Afif Mohd
author_facet	Yusof, Muhd Afif Mohd
author_sort	Yusof, Muhd Afif Mohd
title	Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_short	Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_full	Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_fullStr	Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_full_unstemmed	Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population
title_sort	classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on ki67 index among sabahan population
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42381/1/Dr._Muhd_Afif_Mohd_Yusof-24_pages.pdf
_version_	1747821061436604416

Classification of invasive breast carcinoma according to st gallen classification 2011 with emphasis on Ki67 index among sabahan population

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