Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors

The development in transfusion practice with discovery of advanced cell separators have defined platelet therapy in terms of quality and productivity. Previous studies have shown that transfusion of high yield platelet products could reduce the requirement of transfusion among thrombocytopenic patie...

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Main Author:	Muthalib, Nazri Abdul
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/42417/1/Dr._Nazri_Abdul_Muthalib-24_pages.pdf
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spelling	my-usm-ep.424172019-04-12T05:25:32Z Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors 2016 Muthalib, Nazri Abdul R Medicine (General) The development in transfusion practice with discovery of advanced cell separators have defined platelet therapy in terms of quality and productivity. Previous studies have shown that transfusion of high yield platelet products could reduce the requirement of transfusion among thrombocytopenic patients The aim of this study was to investigate the factors that influence the platelet apheresis yield among apheresis donors by studying the donor variables and machine variables . Differences in donors peripheral count pre and post apheresis procedure were also studied. Correlation of serum ferritin level with platelet apheresis yield was also determined in this study. A prospective study was conducted from September 2015 to August 2016 at Hospital Universiti Sains Malaysia ( HUSM) , Kubang Kerian, Kelantan. Thirty five male subjects were recruited for this study Full blood count ( FBC ) and serum ferritin were taken prior to the donation. Post donation, another sample of FBC was taken. FBC and serum ferritin was run by Diagnostic Stago haematology analyser Sysmex XE 5000 and Bio-Architect respectively. FBC was analysed pre and post donation for haemoglobin level, haematocrit and platelet count. Other donors demographic data which included age, height, weight, frequency of donation and ABO blood group were taken from the donor apheresis registry book. Data regarding machine variables ( anticoagulation infusion rate, processing time and plasma volume collected ) were retrieved from the apheresis machine. The apheresis machine used in this study was Trima Accel cell separator. Height, pre donation platelet count and machine variables revealed significant positive correlations with platelet apheresis yield. There were also significant differences in donor peripheral counts pre and post apheresis procedure. Positive correlation of serum ferritin level with platelet yield was seen. No significant IDA was detected among the apheresis donors. In conclusion, some of the donors’ and all machine related variables showed significant relationship with platelet apheresis yield. There were also significant changes pre and post donation peripheral counts. Donors with high pre platelet count with adequate optimisation of machine variables can potentially produce a higher platelet apheresis yield collection. 2016 Thesis http://eprints.usm.my/42417/ http://eprints.usm.my/42417/1/Dr._Nazri_Abdul_Muthalib-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Muthalib, Nazri Abdul Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
description	The development in transfusion practice with discovery of advanced cell separators have defined platelet therapy in terms of quality and productivity. Previous studies have shown that transfusion of high yield platelet products could reduce the requirement of transfusion among thrombocytopenic patients The aim of this study was to investigate the factors that influence the platelet apheresis yield among apheresis donors by studying the donor variables and machine variables . Differences in donors peripheral count pre and post apheresis procedure were also studied. Correlation of serum ferritin level with platelet apheresis yield was also determined in this study. A prospective study was conducted from September 2015 to August 2016 at Hospital Universiti Sains Malaysia ( HUSM) , Kubang Kerian, Kelantan. Thirty five male subjects were recruited for this study Full blood count ( FBC ) and serum ferritin were taken prior to the donation. Post donation, another sample of FBC was taken. FBC and serum ferritin was run by Diagnostic Stago haematology analyser Sysmex XE 5000 and Bio-Architect respectively. FBC was analysed pre and post donation for haemoglobin level, haematocrit and platelet count. Other donors demographic data which included age, height, weight, frequency of donation and ABO blood group were taken from the donor apheresis registry book. Data regarding machine variables ( anticoagulation infusion rate, processing time and plasma volume collected ) were retrieved from the apheresis machine. The apheresis machine used in this study was Trima Accel cell separator. Height, pre donation platelet count and machine variables revealed significant positive correlations with platelet apheresis yield. There were also significant differences in donor peripheral counts pre and post apheresis procedure. Positive correlation of serum ferritin level with platelet yield was seen. No significant IDA was detected among the apheresis donors. In conclusion, some of the donors’ and all machine related variables showed significant relationship with platelet apheresis yield. There were also significant changes pre and post donation peripheral counts. Donors with high pre platelet count with adequate optimisation of machine variables can potentially produce a higher platelet apheresis yield collection.
format	Thesis
qualification_level	Master's degree
author	Muthalib, Nazri Abdul
author_facet	Muthalib, Nazri Abdul
author_sort	Muthalib, Nazri Abdul
title	Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
title_short	Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
title_full	Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
title_fullStr	Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
title_full_unstemmed	Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
title_sort	factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42417/1/Dr._Nazri_Abdul_Muthalib-24_pages.pdf
_version_	1747821065106620416

Factors influencing platelet apheresis yield and effects of donation among plateler aphersis donors

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