Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia

Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention...

Full description

Saved in:
Bibliographic Details
Main Author: Teoh, Jui Chang
Format: Thesis
Language:English
Published: 2016
Subjects:
Online Access:http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-usm-ep.42520
record_format uketd_dc
spelling my-usm-ep.425202019-04-12T05:25:33Z Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia 2016 Teoh, Jui Chang RD Surgery Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention of post-anaesthesia shivering at 40mcg/kg intravenously. To date, no study has demonstrated the minimum dose of granisetron to prevent post-anaesthesia shivering. This study compared two different dosages of intravenous granisetron versus pethidine for prevention of post-anaesthesia shivering. Methods: This was a prospective, randomized, double-blinded study. A total of 96 patients with ASA classification I and II, aged between 18 and 65 years old scheduled for orthopaedic lower limb surgery under spinal anaesthesia were recruited. Patients were randomly allocated to receive either intravenous (IV) granisetron 10mcg/kg (Group 1), IV granisetron 40mcg/kg (Group 2) or IV pethidine 0.4mg/kg (Group 3) before an intrathecal injection of 15 mg 0.5% hyperbaric bupivacaine. The incidence and severity of shivering with side effects of tested drugs were recorded. Results: The incidence of shivering associated with spinal anaesthesia in our study was not significant different amongst the 3 groups (p = 0.404). However, pethidine was associated with sedative effects when compared with granisetron (p < 0.001). Conclusions: IV granisetron at 10mcg/kg had similar efficacy when compared to both IV granisetron 40mcg/kg and IV pethidine 0.4mg/kg in preventing shivering during spinal anaesthesia for orthopaedic lower limb surgery. 2016 Thesis http://eprints.usm.my/42520/ http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RD Surgery
spellingShingle RD Surgery
Teoh, Jui Chang
Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
description Background: Post-anaesthesia shivering is physiologically and psychologically stressful event. Pethidine, which is commonly recognised as first-line therapy, can have several side effects such as sedative effects, nausea and vomiting. Granisetron has been proven in various studies for prevention of post-anaesthesia shivering at 40mcg/kg intravenously. To date, no study has demonstrated the minimum dose of granisetron to prevent post-anaesthesia shivering. This study compared two different dosages of intravenous granisetron versus pethidine for prevention of post-anaesthesia shivering. Methods: This was a prospective, randomized, double-blinded study. A total of 96 patients with ASA classification I and II, aged between 18 and 65 years old scheduled for orthopaedic lower limb surgery under spinal anaesthesia were recruited. Patients were randomly allocated to receive either intravenous (IV) granisetron 10mcg/kg (Group 1), IV granisetron 40mcg/kg (Group 2) or IV pethidine 0.4mg/kg (Group 3) before an intrathecal injection of 15 mg 0.5% hyperbaric bupivacaine. The incidence and severity of shivering with side effects of tested drugs were recorded. Results: The incidence of shivering associated with spinal anaesthesia in our study was not significant different amongst the 3 groups (p = 0.404). However, pethidine was associated with sedative effects when compared with granisetron (p < 0.001). Conclusions: IV granisetron at 10mcg/kg had similar efficacy when compared to both IV granisetron 40mcg/kg and IV pethidine 0.4mg/kg in preventing shivering during spinal anaesthesia for orthopaedic lower limb surgery.
format Thesis
qualification_level Master's degree
author Teoh, Jui Chang
author_facet Teoh, Jui Chang
author_sort Teoh, Jui Chang
title Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_short Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_full Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_fullStr Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_full_unstemmed Comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
title_sort comparing two different doses of intravenous granisetron versus intravenous pethidine for prevention of shivering in patients undergoing spinal anaesthesia
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Perubatan
publishDate 2016
url http://eprints.usm.my/42520/1/Dr._Teoh_Jui_Chang-24_pages.pdf
_version_ 1747821079010738176