Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries

Background: Hypotension and bradycardia are common side effects of epidural anaesthesia. Speed of epidural injection is a contributing factor. To date, no conclusive study has demonstrated the effects of injection rate upon haemodynamic changes. This study is to compare the effects of different i...

Full description

Saved in:

Bibliographic Details
Main Author:	Chuen, Ting Yung
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RD Surgery
Online Access:	http://eprints.usm.my/42761/1/Dr._Ting_Yung_Chuen-24_pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.42761
record_format	uketd_dc
spelling	my-usm-ep.427612019-04-12T05:25:20Z Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries 2016-06 Chuen, Ting Yung RD Surgery Background: Hypotension and bradycardia are common side effects of epidural anaesthesia. Speed of epidural injection is a contributing factor. To date, no conclusive study has demonstrated the effects of injection rate upon haemodynamic changes. This study is to compare the effects of different injection rate upon haemodynamic parameters, onset and level of blockade in lower limb surgeries. Methods: This prospective, single-blinded randomized controlled study randomized 66 patients into Group 1 (single-injection group) & Group 2 (intermittent-injection group) to receive 10 ml 0.5% bupivacaine and 100 mcg fentanyl at different injection rate. Measurements of vital signs, epidural blockade were taken for 30 minutes. The primary objective is to compare the differences in blood pressure and heart rate between the groups. Other objectives are to compare the differences in onset and level of blockade. Results: Statistical analysis showed significant decrease of mean arterial pressure (MAP) and heart rate in both groups, p < 0.05.However there were no statistically significant in terms of onset of sensory block (p = 0.06), motor block (p= 0.37) as well as level of sensory (p= 0.86) and motor (p= 0.32) blockade in both groups. Conclusions: This study showed epidural injection rate produced significant declines of MAP & heart rate but no difference in term of onset & level of both sensory & motor blockades. 2016-06 Thesis http://eprints.usm.my/42761/ http://eprints.usm.my/42761/1/Dr._Ting_Yung_Chuen-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RD Surgery
spellingShingle	RD Surgery Chuen, Ting Yung Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
description	Background: Hypotension and bradycardia are common side effects of epidural anaesthesia. Speed of epidural injection is a contributing factor. To date, no conclusive study has demonstrated the effects of injection rate upon haemodynamic changes. This study is to compare the effects of different injection rate upon haemodynamic parameters, onset and level of blockade in lower limb surgeries. Methods: This prospective, single-blinded randomized controlled study randomized 66 patients into Group 1 (single-injection group) & Group 2 (intermittent-injection group) to receive 10 ml 0.5% bupivacaine and 100 mcg fentanyl at different injection rate. Measurements of vital signs, epidural blockade were taken for 30 minutes. The primary objective is to compare the differences in blood pressure and heart rate between the groups. Other objectives are to compare the differences in onset and level of blockade. Results: Statistical analysis showed significant decrease of mean arterial pressure (MAP) and heart rate in both groups, p < 0.05.However there were no statistically significant in terms of onset of sensory block (p = 0.06), motor block (p= 0.37) as well as level of sensory (p= 0.86) and motor (p= 0.32) blockade in both groups. Conclusions: This study showed epidural injection rate produced significant declines of MAP & heart rate but no difference in term of onset & level of both sensory & motor blockades.
format	Thesis
qualification_level	Master's degree
author	Chuen, Ting Yung
author_facet	Chuen, Ting Yung
author_sort	Chuen, Ting Yung
title	Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
title_short	Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
title_full	Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
title_fullStr	Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
title_full_unstemmed	Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
title_sort	study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2016
url	http://eprints.usm.my/42761/1/Dr._Ting_Yung_Chuen-24_pages.pdf
_version_	1747821098010935296

Study of lumbar epidural single versus intermittent injection of 0.5% bupivacaine upon onset, level of blockade & haemodynamics in orthopaedic elective lower limb surgeries

Similar Items