The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives

Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(...

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Main Author:	Al-Mudaris, Zena A. Abdul Hameed
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf
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id	my-usm-ep.42887
record_format	uketd_dc
spelling	my-usm-ep.428872019-04-12T05:26:41Z The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives 2011 Al-Mudaris, Zena A. Abdul Hameed RS1-441 Pharmacy and materia medica Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity. 2011 Thesis http://eprints.usm.my/42887/ http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Al-Mudaris, Zena A. Abdul Hameed The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
description	Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity.
format	Thesis
qualification_level	Master's degree
author	Al-Mudaris, Zena A. Abdul Hameed
author_facet	Al-Mudaris, Zena A. Abdul Hameed
author_sort	Al-Mudaris, Zena A. Abdul Hameed
title	The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_short	The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_full	The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_fullStr	The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_full_unstemmed	The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
title_sort	study of anticancer properties of benzyl-o-vanillin and its derivatives
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2011
url	http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf
_version_	1747821120053051392

The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives

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