Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan

The aim of this study was (1) to evaluate demographic factors of patient with hepatocellular carcinoma who underwent TACE procedure (2) to identify the correlation between predictive factors (tumour attenuation, size and site of tumour) and response of tumour (volume of residual viable tumour) to TA...

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Main Author:	Mohamed , Dahlia
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RC799-869 Diseases of the digestive system Gastroenterology
Online Access:	http://eprints.usm.my/42897/1/Dr._Dahlia_Mohamed%28Baru_upload%29-24_pages.pdf
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id	my-usm-ep.42897
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spelling	my-usm-ep.428972019-04-12T05:25:07Z Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan 2017 Mohamed , Dahlia RC799-869 Diseases of the digestive system. Gastroenterology The aim of this study was (1) to evaluate demographic factors of patient with hepatocellular carcinoma who underwent TACE procedure (2) to identify the correlation between predictive factors (tumour attenuation, size and site of tumour) and response of tumour (volume of residual viable tumour) to TACE procedure (3) to determine which predictive factor contribute more to better tumor response to TACE. Patients diagnosed with Hepatocellular carcinoma who underwent TACE procedure using drug eluting microparticles as the embolized material recruited from PACS system at Radiology Department Hospital USM and Hospital Selayang. CT findings (pre and post TACE) of 144 tumors were analysed using several parameters (attenuation, size and site of tumour). Response of tumour to TACE was assessed based on reduction of size of tumour volume. A total of 144 nodules of HCC were analysed from pre- and post-TACE CT scan in arterial phase. Simple linear regression analysis revealed that tumour attenuation and size have significant association with the tumour response to TACE (P<0.001). There were no significant association found between the site of tumour [central or peripheral (p=0.453) and right lobe or left lobe (P=0.705)] with tumour response to TACE. Out of the two statistically significant variables, we found that the strongest predictive factor for better TACE response based on multiple linear regression analysis was the tumour size. Smaller tumor and higher tumour attenuation (measured in Hounsfield unit) were the significant predictive factors for better tumour response to TACE. Location of the tumour showed no statistical significant association with better TACE response. 2017 Thesis http://eprints.usm.my/42897/ http://eprints.usm.my/42897/1/Dr._Dahlia_Mohamed%28Baru_upload%29-24_pages.pdf application/pdf en public masters Universiti Sains Malaysia School of Medical Sciences
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC799-869 Diseases of the digestive system Gastroenterology
spellingShingle	RC799-869 Diseases of the digestive system Gastroenterology Mohamed , Dahlia Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
description	The aim of this study was (1) to evaluate demographic factors of patient with hepatocellular carcinoma who underwent TACE procedure (2) to identify the correlation between predictive factors (tumour attenuation, size and site of tumour) and response of tumour (volume of residual viable tumour) to TACE procedure (3) to determine which predictive factor contribute more to better tumor response to TACE. Patients diagnosed with Hepatocellular carcinoma who underwent TACE procedure using drug eluting microparticles as the embolized material recruited from PACS system at Radiology Department Hospital USM and Hospital Selayang. CT findings (pre and post TACE) of 144 tumors were analysed using several parameters (attenuation, size and site of tumour). Response of tumour to TACE was assessed based on reduction of size of tumour volume. A total of 144 nodules of HCC were analysed from pre- and post-TACE CT scan in arterial phase. Simple linear regression analysis revealed that tumour attenuation and size have significant association with the tumour response to TACE (P<0.001). There were no significant association found between the site of tumour [central or peripheral (p=0.453) and right lobe or left lobe (P=0.705)] with tumour response to TACE. Out of the two statistically significant variables, we found that the strongest predictive factor for better TACE response based on multiple linear regression analysis was the tumour size. Smaller tumor and higher tumour attenuation (measured in Hounsfield unit) were the significant predictive factors for better tumour response to TACE. Location of the tumour showed no statistical significant association with better TACE response.
format	Thesis
qualification_level	Master's degree
author	Mohamed , Dahlia
author_facet	Mohamed , Dahlia
author_sort	Mohamed , Dahlia
title	Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
title_short	Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
title_full	Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
title_fullStr	Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
title_full_unstemmed	Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
title_sort	predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan
granting_institution	Universiti Sains Malaysia
granting_department	School of Medical Sciences
publishDate	2017
url	http://eprints.usm.my/42897/1/Dr._Dahlia_Mohamed%28Baru_upload%29-24_pages.pdf
_version_	1747821122500427776

Predictive factors of trans-arterial chemoembolization (tace) efficacy for hepatocellular carcinoma in arterial phase computed tomographic scan

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