Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches

Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generat...

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Main Author:	Lee , Yie Vern
Format:	Thesis
Language:	English
Published:	2017
Subjects:	R735-854 Medical education Medical schools Research
Online Access:	http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf
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id	my-usm-ep.42910
record_format	uketd_dc
spelling	my-usm-ep.429102019-04-12T05:24:56Z Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches 2017-11 Lee , Yie Vern R735-854 Medical education. Medical schools. Research Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generation cycle during active and latent stage. Instead of focusing on the drug targets during the active stage, which already have the effective therapeutic drugs, this study targeted isocitrate lyase (ICL), a potential target for dormant (latent) MTB energy generation cycle (glyoxylate cycle). Studies showed that without ICL, dormant MTB cannot survives within the lung of a murine model. 2017-11 Thesis http://eprints.usm.my/42910/ http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Penyelidikan Perubatan Molekul
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R735-854 Medical education Medical schools Research
spellingShingle	R735-854 Medical education Medical schools Research Lee , Yie Vern Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
description	Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generation cycle during active and latent stage. Instead of focusing on the drug targets during the active stage, which already have the effective therapeutic drugs, this study targeted isocitrate lyase (ICL), a potential target for dormant (latent) MTB energy generation cycle (glyoxylate cycle). Studies showed that without ICL, dormant MTB cannot survives within the lung of a murine model.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Lee , Yie Vern
author_facet	Lee , Yie Vern
author_sort	Lee , Yie Vern
title	Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_short	Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_full	Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_fullStr	Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_full_unstemmed	Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_sort	screening for potential inhibitors of mycobacterium tuberculosis isocitrate lyase: in silico and in vitro approaches
granting_institution	Universiti Sains Malaysia
granting_department	Institut Penyelidikan Perubatan Molekul
publishDate	2017
url	http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf
_version_	1747821125694390272

Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches

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