Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks

P-glycoprotein (P-gp) is a multidrug transporter, mainly expressed in the intestinal tissue as a secretory efflux protein. Changes in the activity, gene and protein expression of P-gp caused by drugs or herbal compounds will affect oral drug bioavailability and may potentially lead to drug-drug or d...

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Main Author:	Rusli, Noradliyanti
Format:	Thesis
Language:	English
Published:	2017
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/42918/1/NORADLIYANTI__RUSLI.pdf
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id	my-usm-ep.42918
record_format	uketd_dc
spelling	my-usm-ep.429182019-04-12T05:25:00Z Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks 2017-06 Rusli, Noradliyanti R5-920 Medicine (General) P-glycoprotein (P-gp) is a multidrug transporter, mainly expressed in the intestinal tissue as a secretory efflux protein. Changes in the activity, gene and protein expression of P-gp caused by drugs or herbal compounds will affect oral drug bioavailability and may potentially lead to drug-drug or drug-herb interactions. Mitragyna speciosa Korth or Ketum is traditionally used for various ailments but due to its euphoric effects, this plant is often misused by the local population. Although Ketum is a controlled substance in most Asian countries, including Malaysia, its use is not strictly regulated in other parts of the world. Mitragynine is a major bioactive component in the crude extract of the plant and the safety of this alkaloid causing adverse drug interaction via P-gp has not been fully investigated. 2017-06 Thesis http://eprints.usm.my/42918/ http://eprints.usm.my/42918/1/NORADLIYANTI__RUSLI.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Rusli, Noradliyanti Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
description	P-glycoprotein (P-gp) is a multidrug transporter, mainly expressed in the intestinal tissue as a secretory efflux protein. Changes in the activity, gene and protein expression of P-gp caused by drugs or herbal compounds will affect oral drug bioavailability and may potentially lead to drug-drug or drug-herb interactions. Mitragyna speciosa Korth or Ketum is traditionally used for various ailments but due to its euphoric effects, this plant is often misused by the local population. Although Ketum is a controlled substance in most Asian countries, including Malaysia, its use is not strictly regulated in other parts of the world. Mitragynine is a major bioactive component in the crude extract of the plant and the safety of this alkaloid causing adverse drug interaction via P-gp has not been fully investigated.
format	Thesis
qualification_level	Master's degree
author	Rusli, Noradliyanti
author_facet	Rusli, Noradliyanti
author_sort	Rusli, Noradliyanti
title	Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
title_short	Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
title_full	Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
title_fullStr	Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
title_full_unstemmed	Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks
title_sort	determination of mitragynine as a substrate, inducer, or inhibitor of p-glycoprotein drug transporter, and prediction of drug-herb interaction risks
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2017
url	http://eprints.usm.my/42918/1/NORADLIYANTI__RUSLI.pdf
_version_	1747821127645790208

Determination Of Mitragynine As A Substrate, Inducer, Or Inhibitor Of P-Glycoprotein Drug Transporter, And Prediction Of Drug-Herb Interaction Risks

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